Health
Researchers suggest how brain games predict risk of viral infection
If your attention and reaction speed are more variable than usual, you may be more susceptible to viral illness.
The study was led by experts from the University of Michigan, working closely with colleagues at Duke University School of Medicine and the University of Virginia.
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Alfred Hero, John H. Holland Distinguished University Professor of Electrical Engineering and Computer Science at UM, said: Corresponding author of the study in Scientific Reports.
“This is the first exposure study in humans to show that cognitive performance before exposure to a respiratory virus can predict the severity of infection,” he said.
Subtle changes in daily cognitive performance may indicate changes in brain conditions known to increase the risk of diseases such as stress, fatigue and sleep deprivation. The team wanted to measure cognitive function and investigate whether it could predict immune performance after exposure to respiratory viruses. was found to be highly predictive.
The team studied a cohort of 18 healthy volunteers who underwent brain function tests three times a day for three days before being exposed to a common cold virus known as human rhinovirus. The software provided 18 measures of cognitive function, including reaction time, attention, and rapid switching between numbers and symbols, which were combined to derive an index of variability.
“Initially, because we used raw scores, we didn’t see a significant association between cognitive function and susceptibility to disease: immunity and susceptibility,” says Yaya Zhai, a recent Ph.D. says. Graduated in bioinformatics at UM and lead author of the study. She and Hero led the development of the Cognitive Variation Index.
The team assessed viral shedding by flushing the participants’ nasal passages with saline. They determined the presence of viral infection and the amount of virus in the fluid by growing the virus in cell culture. For symptoms, the team used the Jackson His Score, in which participants rated themselves on his 1 to 3 on her eight common cold symptoms.
“This is an interesting observation from a relatively small study. We hope that we will have the opportunity to confirm these findings in a larger, more definitive study,” said Emeritus Professor of Pediatrics at the University of Virginia. experiment.
The team is optimistic that smartphone use could ultimately help identify when people are more susceptible to illness by monitoring cognitive metrics such as typing speed and accuracy and how long users sleep. am.
said P. Murali Doraiswamy, director of the Neurocognitive Disorders Program at Duke University School of Medicine. Neurocognitive testing part of the study.
“At home, regular cognitive monitoring via self-test digital platforms is the future of brain health assessment,” says Doraiswamy.
The study was part of a project funded by the Defense Advanced Research Projects Agency to find out whether it can predict a soldier’s susceptibility to disease. The project was led by Jeffrey Ginsberg, then Professor of Applied Genomics and Precision His Medicine at Duke University, who led a delegation of teams to analyze blood samples for biomarkers that could indicate susceptibility to disease. bottom.
The experiment also uncovered several genetic markers that may indicate compromised immune function, which the team may investigate further in future studies.
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