Health
A protein secreted by skeletal muscle cells that aids in muscle repair and growth
Scientists at Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor subunit B (PDGF-B) is continuously secreted by skeletal muscle cells and promotes the proliferation of myoblasts (muscle stem cells), thereby promoting muscle growth. I have found that it helps with healing. Surprisingly, they found that his PDGF-B also helped muscle fiber growth. They confirmed that this corresponds to fibers that contract more strongly. Their findings promise innovative therapies for treating muscle atrophy and injury.
Myokines are small proteins secreted by skeletal muscle cells. They have a wide range of functions and can act on cells both near and far from where they are made. , is thought to play an important role in exercise-related bodily functions, especially in the maintenance of muscle tissue.
A team led by Associate Professor Yasuko Manabe of Tokyo Metropolitan University has studied how myokines influence the behavior of muscle cells. Through extensive experiments, they found that a myokine known as platelet-derived growth factor subunit B or PDGF-B is secreted from skeletal muscle in a constitutive manner, ie, without stimulation. To understand what role it plays, they took myoblasts, the progenitor cells that differentiate into muscle fibers, and exposed them to her PDGF-B. They were able to clearly show that PDGF-B induced greater proliferation of myoblasts.
Interestingly, they also found that PDGF-B affects already differentiated cells. They took myotubes, which are stages of muscle fiber development, and exposed them to the same myokines. Myotubes treated in this manner significantly matured and visibly increased in diameter under microscopy. They also expressed more myosin heavy chain, a key part of the protein structure of myosin, the molecular motor responsible for muscle contraction. It was shown that this directly corresponds to an increase in contractile strength, using a recently developed technique based on . So PDGF-B not only builds muscle, it strengthens it. But this does not mean that both processes are accelerated haphazardly. They noted subtle differences in PDGF-B signaling pathways between myotubes and myoblasts. The team believes that these differences may play a role in the cells switching from proliferative to mature phases.
The team’s research clearly shows that PDGF-B is involved in muscle regeneration, making it an important candidate for developing effective treatments for muscle damage and wasting, as well as regimens that improve muscle performance. It constitutes a big leap.
sauce:
Journal reference:
Hamaguchi, H., and others. (2022) PDGF-B secreted from skeletal muscle promotes myoblast proliferation and myotube maturation through activation of the PDGFR signaling cascade. Biochemical and Biophysical Research Communication. doi.org/10.1016/j.bbrc.2022.11.085.
|
Sources 2/ https://www.news-medical.net/news/20230116/Protein-secreted-from-skeletal-muscle-cells-and-helps-to-repair-and-grow-muscles.aspx The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
