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Cell reprogramming extends mouse lifespan, says longevity startup

Cell reprogramming extends mouse lifespan, says longevity startup

 


Billions of dollars are pouring into longevity startups as more studies show that aging may be as inevitable as we assumed. Now the startup claims to have reached a major milestone by extending the lifespan of healthy mice using a promising approach called cellular reprogramming.

In 2017, scientists at the Salk Institute for Biology in San Diego showed for the first time that resetting epigenetic markers can rejuvenate mouse cells. Activity of specific genes. These changes have long been suspected to play an important role in the aging process.

Researchers have found that this approach can prolong life As much as 30% in mice, it significantly rejuvenates some tissues, but the experiments were done in animals with the same progeria (a disease that accelerates human aging) as mice.

It was unclear whether this kind of lifespan extension translates into normal healthy mice, but now rejuvenation bio I suggest that youNo peer review Papers published on preprint servers Bio Rxiv They claim that this approach can double the remaining lifespan of aged mice.

Aging cannot currently be prevented, but its impact on longevity and healthspan may be minimized through interventions aimed at returning gene expression networks to optimal function. said in a press release“The results of this study suggest that partial reprogramming is a potential treatment for the elderly to reverse age-related diseases and may extend human lifespan.” ”

Cell reprogramming builds on the work of Nobel Prize-winning Shinya Yamanaka, who showed that adult cells can be reverted to stem cells by exposing them to a specific set of genomic regulatory proteins known as transcription factors. I’m here. Salk’s team’s innovation was to reduce the time of exposure to the so-called Yamanaka factor, which can reverse epigenetic changes without turning the cell back into a stem cell.

While this approach clearly increased lifespan in prematurely aged mice, the fact that no one has since been able to replicate the results in healthy mice casts doubt on this approach. Several groups have attempted this experiment, but so far the data have been negative,” said Alejandro Ocampo of the University of Lausanne, Switzerland, who conducted the first Salk experiment. . Said MIT Technology Review.

But now, Rejuvenate Bio says that when they exposed healthy mice near the end of their lives,ves In the Yamanaka factor subset, they lived an average of 18 more weeks, compared with only 9 weeks. week for those that have not undergone cellular reprogramming.

Since the mice were already 124 weeks old at that point, this only increased lifespan by 7%. But the company says this is an important demonstration of the potential life-extending power of cell reprogramming, and treated mice also showed improvements in various health indicators.

Another reason this study is interesting is the method. To Yamanaka factor was administered. Previous studies have generally relied on genetically modified mice to generate the factor itself, but this study repurposed it, an approach used in clinically approved gene therapy. used viruses to deliver them to animal cells.

The results have not yet been peer-reviewed, so we will have to take them with a pinch of salt until other groups can replicate them, but there is growing evidence of potential therapeutic benefits. of Cell reprogramming.Recent research on mice shows that it can Promotes liver regeneration and help me vision recovery in glaucomatous animals.

There are serious question marks about potential side effects, including concerns that the approach may increase cancer risk, so it could be a long way to human trials. Recent research Long-term treatment with Yamanaka factor showed significant results in Salk team mice rIt has a rejuvenating effect on animal tissues without causing cancer. The study also found that the longer the treatment time, the better the outcome.

More work needs to be done to validate the Rejuvenate Bio study, but the results ares It suggests that treatments that reverse aging may be within reach soon.

Image credit: Alexa / Pixabay

Sources

1/ https://Google.com/

2/ https://singularityhub.com/2023/01/16/cellular-reprogramming-extends-lifespan-in-mice-longevity-startup-says/

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