Health
Salmonella in the gut can cause neurological disorders like Parkinson’s disease
Salmonella is a bacterium that causes enteric infections from contaminated food and water. Recently, it was discovered that Salmonella in the gut is associated with neurological disorders such as Parkinson’s disease and Alzheimer’s disease.
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Collaboration between the University of Saskatchewan (USask) and Temple University (Philadelphia, US) vaccines and the Center for Infectious Diseases International Vaccine Center (VIDO-InterVac) analyzed Effects of Salmonella biofilm proteins on animals. They observed that bacteria could cause arthritis and autoimmune reactions.
Salmonella biofilm It is usually formed in an environment such as the surface where raw meat is prepared. Biofilm is a bacterium that attaches densely in response to harmful conditions such as disinfectants and antibiotics.
Dr. Aaron White, an expert on Salmonella biofilms and curly amyloid, has, along with his team, discovered that Salmonella biofilms are forming in the intestine of infected mouse models. The biofilm protein “curly” has emerged as scientists have recreated food poisoning associated with bacteria.
Within 4 to 6 weeks, curls formed in the mouse colon and cecum, or the beginning of the large intestine. Scientists also denied that curly was produced only by Salmonella, not by other bacterial species.
Neurological disease
of Curly A protein is a type of amyloid that is the same protein associated with neurological disorders such as Parkinson’s disease, Alzheimer’s disease, and Rogerig’s disease, or Amyotrophic lateral sclerosis (ALS). This is important information because amyloid plaques, or protein masses, disrupt the connections between neurons in neurodegenerative diseases.
It is speculated that these disorders cause curly activity. White explains:
There was speculation that bacteria could stimulate Amyloid plaque It contributes to Alzheimer’s disease, Parkinson’s disease, ALS formation and disease progression. The discovery of curly in the intestine may represent an important link pointing out potential causes of these diseases.
Shagratukel and her team at Temple University have discovered that Kali causes autoimmune reactions and arthritis as a result of Salmonella. “In mice, these reactions are triggered within six weeks of infection, indicating that Curly may be a major driver of the autoimmune reaction,” she said.
Also read: Health Note: A Salmonella Pediatric Case Connected to a Queensland Backyard Chicken
Autoimmunity
Autoimmune disease Abnormal activity of the immune system causes the body to self-damage due to lack of activity or overdrive. Rheumatoid arthritis is an example of immune cells causing inflammation in joints.
The immune system, which produces harmful antibodies, can cause permanent joint damage. The goal of the team is to see the same reaction in humans.
It also means that food-borne bacteria such as E. coli and Listeria can cause an autoimmune reaction like Salmonella. “This important finding suggests that foodborne pathogens may initiate or worsen autoimmunity and contribute to amyloid disorders such as Alzheimer’s and Parkinson’s disease.”
Also read: Suppressor gene found to protect brain from Alzheimer’s disease
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