Health
Bacteria in infants’ first stool may indicate their risk of obesity
London: Researchers have shown that bacteria in meconium — the earliest stools in infants — may indicate a risk for their obesity.
Meconium is made up of substances taken during the time an infant spends in the womb. The study, published in the Journal of Childhood Obesity, found that obesity can predict the type of normal bacteria found in meconium, which can cause an infant to later develop obesity.
Several reports have shown that firstapass meconium hosts a diverse microbiota, but its clinical significance is unknown.
“We designed a population-based prospective cohort study to assess whether the meconium microbiome predicts subsequent growth in children,” said study authors at the University of Oulu, Finland.
A study of 212 newborns showed that overweight children at age 3 had a higher proportion of bacteria in the phylum Bacteroides, unlike those with normal meconium bacterial composition (29% vs. 15%). ).
Findings showed that the first-pass meconium microbiota predicts subsequent overweight at the age of 3 years. “The concept of the fetal microbiome is controversial, and the postnatal colonization process is better understood than the possible fetal colonization,” said Oulu University researcher Kaja Colpera.
“But there are many prenatal factors that influence the microbial composition of the baby’s first stool, such as the mother’s use of antibiotics during pregnancy and the biodiversity of the home environment during pregnancy,” Colpera added. It was
In conclusion, the research team showed that the microbiome of first-pass meconium formed during pregnancy was associated with overweight after the same 3-year-old child.
This result emphasizes the importance of investigating maternal and prenatal factors when examining the etiology of childhood obesity.
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