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Better ways to keep mosquitoes at bay are in development


M.mosquito repellent We’ve come a long way.For decades the market leader Deet, fend off pests well, but only for 1-2 hours. Recently, Icaridin became available.It lasts up to 8 hours and is equally effective. However, both are mildly toxic to cells grown in culture, and their toxicity (if any) to human users is constantly debated. looking for something beyond doubt not toxic at all.

Francesca Dani of the University of Florence in Italy thinks there may be an answer.she and her colleagues Journal of Agro-Food Chemistrythey looked at various chemicals called aldehydes and ketones and tweaked them a bit to produce what seemed to be a good, long lasting and safe mosquito repellent.

Dr. Dani knew from the scientific literature that aldehydes and ketones had insect repellent properties. But such chemicals evaporate faster. DeetBut she also knew from her own research that molecules called hydroxylated cyclic acetals, which form from certain aldehydes and ketones when exposed to alcohol, are difficult to evaporate. no, she thought.

She and her colleagues created a number of hydroxylated cyclic acetals and tested their mosquito repellent properties against other acetals. Deet and Icaridin. The standard way to do this is to spray a portion onto the back of a volunteer’s hand and place both hands in a mosquito cage. , can determine the effectiveness of a particular chemical repellent.

As expected, Deet The protection efficiency was 95% (calculated by subtracting the number of treated hand mosquitoes from the number of untreated mosquitoes, dividing by the number of untreated mosquitoes and multiplying by 100). Such protection was conferred by applying 8.3 micrograms per square centimeter of her skin and lasted for two hours. For Icaridin, one-fifth the dose provided equivalent repulsion over 8 hours.

To the researchers’ delight, two of the hydroxylated cyclic acetals performed similarly to icaridin. And when they tested them in cell culture, they found that what they called 12a in the paper for simplicity didn’t kill any of the cells exposed to it.

Deet and Icaridin perform well. Deet Developed in the 1940s to protect American soldiers from mosquito-borne diseases during the war. Icaridin with a longer shelf life appeared in the 2000s. However, if 12a passes, both could reach the end of their useful life soon.




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