First NHS-recommended CAR T-cell therapy

Yescarta recommended by NICE^® This means that this is the first time patients will have access to long-term CAR T-cell therapy in the NHS.

Yescarta^® ▼(axicabtagene ciloleucel; axi-cel) is now the first chimeric antigen receptor (CAR) T-cell therapy and the first personalized immunotherapy recommended for routine use in the UK NHS. It is based on the final draft guidance from the National Institute for Health and Care Excellence (NICE).

Treatment with Gilead Sciences and Kite Eligible for Diffuse Large B-cell Lymphoma (DLBCL) and Primary Mediastinal Large B-cell Lymphoma (PMBCL) Previously Treated with ≥2 Systemic Therapies It is intended for adults.

In 2018, the UK, through the Cancer Drugs Fund (CDF), became the first European country to offer access to CAR T-cell therapy to treat these blood cancers. Since then, over 500 of her patients in the UK have received axi-cel.

Helen Knight, Director of Drug Evaluation at NICE, said: [use of Yescarta^®] CDF and clinical trials have shown that it can provide effective treatments, extend people’s lives and improve their quality of life. ”

“CAR-T therapy offers hope to people living with the most aggressive types of hematological cancers…the risk of recurrence and the uncertainty about the treatment options available to them can be a source of distress. may increase… [so this recommendation] Blood Cancer UK CEO Helen Rowntree said:

What is CAR-T cell therapy?

CAR T-cell therapy is a patient-focused, individualized treatment currently approved for patients with certain types of advanced hematological cancers. CAR T-cell therapy manipulates the patient’s own immune cells (T cells) to detect, target, and destroy cancer cells.

According to guidelines published in 2016, after initial chemotherapy, up to 45% of patients with DLBCL will require second-line therapy, often requiring high-dose chemotherapy and stem cell transplant. British Journal of HematologyAbout 50% of people who have a transplant will eventually relapse, a study published in 2017 was published in the journal. bloodThis decision ensures that these patients can continue to receive CAR T-cell therapy in the 3rd line setting.

Axi-cel will be made available routinely in a third line setting for all eligible DLBCL and PMBCL patients in the NHS. ”

Dr. Véronique Walsh, Vice President and General Manager, Gilead Sciences UK and Ireland, commented:

Final Draft Guidance Related to NICE Recommendations Available here.

EC approves CAR T-cell therapy for B-cell lymphoma

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