Blood tests may detect the condition before diagnosis

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• Researchers say they are developing a blood test that can potentially detect Alzheimer’s disease more than three years before clinical diagnosis.
• They say the test could be used to start treatment for Alzheimer’s disease earlier.
• Experts say more research is needed, but if the test proves to be viable, it could be an important step in the diagnosis and treatment of Alzheimer’s disease.

Scientists say they developed a test that could potentially detect Alzheimer’s disease years before people commonly received a clinical diagnosis.

their new study,It was published in the magazine brainresearchers report that their blood-based test can identify atypical brain cell activity in people who may later be diagnosed with Alzheimer’s disease.

When Alzheimer’s disease — A disease that causes memory, language and cognitive problems — Your brain begins to change 20 years before symptoms of Alzheimer’s appear.

Currently available medicines are most effective when given in the preclinical stage, and researchers believe that this type of testing can identify and significantly improve outcomes in people in the early stages of Alzheimer’s disease. said to be useful for

“These results are intriguing and may provide a new way to assess cognitive progression in patients with MCI.” Dr. David M. Holtzmanwas a professor of neurology at the Washington University School of Medicine in St. Louis and former president of the American Academy of Neurology.

To understand how neurogenesis is altered in people who develop Alzheimer’s disease, researchers collected blood samples from 56 people with mild cognitive impairment (MCI) over two to five years.

MCI is often an early indicator of Alzheimer’s disease. For example, in this study, 36 of his 56 participants were later diagnosed with Alzheimer’s disease.

The researchers then treated brain cells with blood taken from the participants to see how the cells changed when exposed to blood as the participants’ cognitive decline progressed.

The team reported less brain cell growth and division and more cell death among MCI participants who subsequently developed Alzheimer’s disease.

Those same blood samples also boosted the normal amount of immature brain cells that converted into hippocampal neurons – a process called neurogenesis.

Researchers suspect that the reason for this unexpected neurogenesis is that the brain is compensating for neurodegeneration or brain cell loss.

Researchers say the blood-based test can predict progression from MCI to Alzheimer’s disease more than three years before clinical diagnosis.

More research is needed to validate the findings and evaluate the test in a more diverse group of people, the researchers said in their paper.

“Although more research needs to be done before this can be used in the general population, it’s a good step towards finding a more accurate and early diagnosis of Alzheimer’s disease.” Dr. Jessica LeeUTHealth Houston and Memorial Hermann geriatrician told Healthline.

According to Holtzman, some people with MCI have underlying Alzheimer’s pathology in their brains, while others have MCI without underlying Alzheimer’s disease pathology.

There are other causes of cognitive impairment that can be identified by medical tests.

Holtzman believes that researchers may have benefited from the use of imaging, cerebrospinal fluid, or plasma biomarkers to identify the cause of MCI.

“This makes it difficult to know whether the effects of serum on in vitro assays that predict cognitive decline underlie Alzheimer’s disease or are due to other causes,” Holtzman told Healthline. rice field.

That said, Lee said the new report highlights a new and exciting potential way to detect Alzheimer’s disease early through low-risk, inexpensive tests.

Currently, people can only get a possible diagnosis of Alzheimer’s disease through a battery of imaging tests, laboratory studies, memory tests, and physical health assessments.

According to Dr. Lee, a definitive diagnosis of Alzheimer’s disease can only be obtained through a brain autopsy after a person has died.

“If we can predict the onset of dementia well in advance, it gives patients the opportunity to plan ahead regarding their family, finances and goals,” said Lee.

Scientists have developed a blood-based test that may detect Alzheimer’s disease years before it is commonly diagnosed clinically.

The brain begins to change years before symptoms of Alzheimer’s disease appear, and this type of test may help identify people in the early stages of Alzheimer’s disease progression.

More research is needed to validate the findings, but the findings suggest that medical professionals 6 million people 65+ in the US.

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