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Gum infections may be a risk factor for arrhythmia, researchers find

Gum infections may be a risk factor for arrhythmia, researchers find

 


Periodontal disease, periodontal disease, can cause a variety of dental problems, from bad breath to bleeding to tooth loss. Now, researchers at Hiroshima University have discovered that it may be linked to an even more serious problem elsewhere in the body: the heart.

In a study published on October 31, JACC: Clinical ElectrophysiologyIn a sample of 76 patients with heart disease, the team found a significant correlation between periodontitis and fibrosis (scarring of the left atrial appendage of the heart leading to irregular heartbeats called atrial fibrillation). I discovered that there is

“Periodontitis is associated with long-term inflammation, and inflammation plays an important role in the progression of atrial fibrosis and the pathogenesis of atrial fibrillation,” says lead author Shunsuke Miyauchi, assistant professor at the Hiroshima University Health Center. He also belongs to the Graduate School of Medicine, Dentistry, Pharmaceutical and Health Sciences at the same university. “We hypothesized that periodontitis exacerbates atrial fibrosis. This histological study of the left atrial appendage demonstrated the relationship between clinical periodontitis status and degree of atrial fibrosis.” We aim to clarify.”

The left atrial appendage was surgically removed from the patient and the researchers analyzed the tissue to establish a correlation between the severity of atrial fibrosis and the severity of periodontal disease. They found that fibrosis worsened with worsening periodontitis, suggesting that gum inflammation may exacerbate heart inflammation and disease.

“This study provides basic evidence that periodontitis can exacerbate atrial fibrosis and may be a new modifiable risk factor for atrial fibrillation,” said Dr. The author, Yukiko Nakano, professor of cardiovascular medicine at the Hiroshima University Graduate School of Biomedical and Health Sciences, said.

According to Nakano, in addition to improving other risk factors such as weight, activity level, and tobacco and alcohol use, periodontal care may help in comprehensive atrial fibrillation management. Studies have not established a causal relationship—that is, although the severity of periodontal disease and atrial fibrosis appear to be related, researchers have found that one conclusively leads to the other. She warned that it meant no.

“Further evidence is needed to establish that periodontitis causally contributes to atrial fibrosis and that periodontal care can alter fibrosis,” Nakano said. One of our goals is to confirm that periodontitis is a modifiable risk factor for atrial fibrillation and to facilitate the participation of dental professionals in comprehensive atrial fibrillation management. is a low-cost and easily modifiable target among the known risk factors for atrial fibrillation, so the results of this study series may benefit many people around the world.”

Next, the researchers hope to conduct future clinical trials to determine whether periodontal interventions reduce the incidence of atrial fibrillation and improve patient outcomes.

Sources

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2/ https://www.sciencedaily.com/releases/2023/01/230127131143.htm

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