Health
Common antidepressants may increase antibiotic resistance – UQ News
Researchers at the University of Queensland have found that a range of commonly prescribed antidepressants can make bacteria more resistant to antibiotics.
Research led by Professor Jianhua Guo From UQ Australian Water Environment Biotechnology Center Focuses on prescription drugs used to treat Depressive disorders, anxiety disorders, and other psychological conditions.
More than 42 million antidepressant prescriptions will be issued in Australia in 2021. In this study, sertraline (Zoloft), escitalopram (Lexapro), bupropion (Wellbutrin), duloxetine (Cymbalta), and agomelatine (Valdoxan).
“Although overuse of antibiotics is recognized as a major factor in bacterial resistance, we wanted to investigate whether other common drugs contributed to the problem,” said Professor Guo.
“Sertraline, duloxetine, and fluoxetine had the strongest impact on bacterial resistance to antibiotics of the drugs we tested.
“Our study showed that even very low doses significantly increased resistance to these three antibiotics.
“Notably, antibiotic resistance appears to be dependent on antidepressants, which may be due to antidepressant-induced bacterial oxidative stress.
“Further research is needed to assess potential effects on the microbiome in people receiving antidepressants and to assess risk for gastrointestinal disturbances and disease.”
It is estimated that 1.27 million people die each year from infections that do not respond to drugs; expected to reach 10 million By 2050 unless global action is taken
This research Proceedings of the National Academy of Sciences (PNAS) was funded by Australian Research Council Discovery Projectand the UQ Foundation Research Excellence Award.
Image: Dr. Yue Wang (left) and Prof. Jianhua Guo (right)
Media: Professor Jianhua Guo, jianhua.guo@uq.edu.au+61 7 3346 3222, +61 426 668 158; Sharon James, Australian Water Environment Biotechnology Centre, sharon.james@uq.edu.au+61 404 624 773.
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Sources 2/ https://www.uq.edu.au/news/article/2023/01/common-antidepressants-can-increase-antibiotic-resistance The mention sources can contact us to remove/changing this article |
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