Health
Newly discovered SARS-CoV-2 viral receptor LRRC15
Dear Editor,
An Australian team from the University of Sydney has reported the identification of a new SARS-CoV-2 viral receptor named ‘leucine-rich repeat containing protein 15’ (LRRC15) (Loo et al., 2023).
This molecule shares high binding affinity to the ACE-2 receptor and the SARS-CoV-2 viral spike (S) protein and is found to be predominantly expressed by lung and myofibroblasts. I already know. skin and upper respiratory tract.
Nevertheless, after SARS-CoV-2 binds to LRRC15, the virus is ‘sequestered’ by lung (muscle) fibroblasts and access to ACE-2-expressing bronchiolar and alveolar epithelial cells is blocked. will be It increased the production and surface exposure of LRRC15 and suppressed subsequent viral spread.
Thanks to their outstanding contributions, these Australian researchers found that, in parallel with the expression of LRRC15, fibroblasts suppress collagen biosynthesis, which may contribute to the chronic disease of COVID-19/associated pneumonia. It also made me realize that it hinders progress. It is characterized by extensive pulmonary fibrosis. In addition, increased production of antiviral factors of the IFIT, OSA, and MX families has also been reported following SARS-CoV-2-LRRC15 interaction (Loo et al., 2023).
In conclusion, the newly discovered LRRC15 receptor molecule appears to be a key determinant of host susceptibility/resistance to SARS-CoV-2 infection and thus the scale and severity of COVID-19 disease. This, together with other non-ACE-2 viral receptors such as ‘neuropilin-1’ (Di Guardo, 2022), contributes to the differential susceptibility/resistance of domestic and wildlife host species to natural and SARS-CoV-. It may also contribute to regulation. 2 Contagion, thereby giving special consideration to the concept of “one health” and reminding us that human, animal and environmental health are interrelated and closely related to each other!
References
1) Di Guardo G. SARS-CoV-2 susceptibility in domestic and wild mammals: Is it all about the similarity of ACE2 receptors to humans? Proc Biol Sci. 9 February 2022;289(1968):20212560. Doi: 10.1098/rspb.2021.2560.
2) Loo L, Waller MA, Moreno CL, Cole AJ, Stella AO, Pop OT, etc. (2023) fibroblast-expressed LRRC15 is a receptor for the SARS-CoV-2 spike and regulates antiviral and antifibrotic transcriptional programs. PLoS Biol 21(2): e3001967. doi:10.1371/journal.pbio.3001967.
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Sources 2/ https://www.bmj.com/content/380/bmj-2022-072529/rr-4 The mention sources can contact us to remove/changing this article |
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