US scientists may have found a way to increase human life-World News

Scientists at a university in Southern California, USA may have found the beginning of the path needed to extend human life.

A study by the team at the USC Donife College of Letters Arts and Sciences, published by the Journal of Gerontology: Biological Sciences on July 10th, showed that the drug Mifepristone is used in laboratory research in two very It shows that the lifespan of different species can be extended.

Clinicians use mifepristone, also known as RU-486, to treat cancer and Cushing’s disease as well as end early pregnancies.

Studies, female Drosophila mating, sex peptides and metabolic signatures of lifespan regulated by mifepristone/RU486 also suggest that findings may be applicable to other species, including humans ..

John Tower, a professor of biological sciences at the USC Donife College of Arts and Sciences, and his team have discovered that Mifepristone extends the life of female Drosophila females.

Female fruit flies receive sex peptides from males during mating, and previous studies have shown that the molecule causes inflammation and shortens the health and longevity of female flies.

Giving mifepristone to mating Drosophila blocks the effects of sex peptides, reduces inflammation, keeps female flies healthy, and responds to the tower and his team of non-medicinal responders (Senior Gary. Found a researcher and lead investigator who will have a longer lifespan (including Landis).

The effects of the drug in Drosophila appear similar to those seen in women who take it.

“In situ, mifepristone reduces fertility, alters the innate immune response, and prolongs lifespan,” Tower said. “In humans, do we know that mifepristone diminishes reproduction and alters the innate immune response, so does it prolong life?” The Tower is an open-access healthcare and life science hub. It was quoted as said by News Medical.

The team explored the genes, molecules, and metabolic processes that changed when the flies were drugged to better understand how mifepristone functions to prolong life.

They found that molecules, called juvenile hormones, that regulate the development of Drosophila throughout life, from eggs to larvae to adults, play a central role.

Sex peptides seem to escalate the effects of juvenile hormones and shift the metabolism of mating flies from healthier processes to metabolic pathways that require more energy. Studies show that metabolic shifts promote deleterious inflammation, which appears to make flies more sensitive to toxic molecules produced by bacteria in their microbiota.

When mated flies ate the drug, their metabolism stagnated in a healthier pathway and outlived their mating sisters who did not take mifepristone. According to News Medical, Tower says these metabolic pathways are conserved in humans and are associated with health and longevity.

Tower and his co-workers also found that the small roundworm, C elegans, was given the same drug, and mifepristone had the same life-prolonging effect on mated worms.

Since the evolution of Drosophila and D. elegans in Drosophila is relatively distant, similar results in these different species suggest that other organisms, including humans, may offer the same benefits as longevity. ..

He said the fact that mifepristone can extend the lifespan of both species suggests that the mechanism is important for many species.

“Our data show that in Drosophila, mifepristone directly or indirectly counteracts juvenile hormone signaling, but the precise target of mifepristone remains elusive.” Tower said according to News Medical.

Before a firm conclusion can be drawn, a more clear understanding of the complexity of mifepristone’s behavior needs to be understood, Tower added.