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Asthma, Eczema Associated With Higher Risk Of Osteoarthritis, Stanford-Led Study Finds News Center

Asthma, Eczema Associated With Higher Risk Of Osteoarthritis, Stanford-Led Study Finds News Center


The researchers found and followed people who had been osteoarthritis-free for two years and subsequently diagnosed with asthma or eczema. The investigators then matched each diagnosed patient with a control group and matched them with similarities in demographics, frequency of visits, presence of other diseases, and several other factors. and confirmed who developed osteoarthritis. In the primary cohort, each group had approximately 110,000 patients.

Paving the way for therapeutic success

The authors found that patients with asthma or eczema had a 58% increased risk of developing osteoarthritis over about 10 years. Having both asthma and eczema increased the risk to 115%.

To confirm the effects of other lung diseases not mediated by allergens, researchers compared chronic obstructive pulmonary disease, in which airflow from the lungs is constricted, to asthma. They found that asthma patients had an 83% higher risk of developing osteoarthritis compared with COPD patients. , again suggesting that the activation of allergic pathways is an important factor.

Because the primary analysis claim data did not include body mass index, a risk factor for osteoarthritis, the researchers validated the results with an independent dataset using the Stanford Research Repository.The results were similar. , indicating that allergic diseases increase the risk of developing osteoarthritis, even after considering the important variables of BMI.

According to Dr. Baker, existing drugs for asthma attacks and mast cell activation syndrome (a condition in which patients repeatedly experience anaphylactic symptoms) may be candidates for treatment of osteoarthritis. Inhibits cells and allergic cytokines (byproducts of mast cells that cause inflammation).

“There is strong potential to study this as an intervention to see if targeting pathways such as inhibiting mast cells or allergic cytokines can actually reduce the onset and progression of osteoarthritis.” We have a solid foundation,” said Baker.

Researchers at Chinook Therapeutics in Seattle, Boston University School of Medicine, and VA Palo Alto Health Care System contributed to this work.

This study was funded by the National Institutes of Health (grant R25 AI 147369 and P30 072571), Veterans Affairs, Department of Defense, Stanford Center for Clinical and Translational Research and Education.




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