Health
Experts discover gut bacteria that reduce risk of heart disease • Earth.com
Expert Ohio State University We have identified types of intestinal bacteria that reduce the risk of heart disease. The heart health benefits of this bacterium, Eubacterium limosum, were previously unrecognized.
E. rimosum activity reduces the production of chemicals in the intestine associated with arterial blockage in a condition known as atherosclerosis. After the chemical is produced, it travels through the bloodstream to the liver where it is converted to a more harmful form.
Researchers E. We have linked the beneficial behaviors of rimosum to specific protein families. This link helps explain how good gut bacteria contribute to human health.
In the intestine, good and bad bacteria compete for the same nutrients. By helping eliminate bad organisms, good bacteria can prevent health problems that can occur as a result of metabolic problems.
Further research is needed, but experts believe that E. limosum has many potential uses for therapeutic purposes. Previous studies have already established that bacteria subside inflammation in the intestine.
“In the last decade, it has become clear that bacteria in the human gut affect our health in many ways,” said Joseph Krzycki, the lead author of the study. “The organisms we study affect health by preventing the problematic compounds from deteriorating.”
“It’s too early to say if this bacterium has therapeutic value. But that’s what we are aiming for.”
The chemical associated with a blocked artery is called trimethylamine (TMA). It is produced during metabolism when gut microbes, usually the bad type of gut bacteria, interact with certain nutrients from food. One such nutrient is L-carnitine, a meat and fish compound often used as a supplement to improve post-exercise recovery.
Researchers E. It was discovered that rimosum interacts with L-carnitine differently in the intestine, eliminating the role of L-carnitine in TMA production.
The beneficial behavior of bacteria results from the protein MtcB, an enzyme involved in demethylation. This process modifies the structure or function of a compound by removing the methyl group.
Studies show that E Rimosum is exposed to L-carnitine, and bacteria synthesize the MtcB protein to specifically target and cleave the methyl group of L-carnitine.
“Bacteria do this for their own benefit, but it has the downstream effect of reducing the toxicity of TMA,” said Krzycki. “So far, the only known intestinal microbial reaction with L-carnitine has involved converting it to its bad form.”
“We have found that bacteria that are known to be beneficial can remove the methyl group and send the resulting product to another pathway without making other harmful compounds in the process. “
According to Professor Krzycki, finding this important health benefit with one of the intestinal bacteria could affect how the intestinal bacteria affect the health outcomes associated with human metabolism. Suggests that there is still a lot to learn about.
“MtcB is part of the protein family, and thousands of representatives can use different compounds to alter the nutrients that bacteria consume in the intestine,” says Krzycki. “These proteins may behave very much chemically, but biologically, the use of different compounds can clearly make a big difference.”
This study Journal of Biological Chemistry..
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Along Chrissy Sexton, Earth.com Staff writers
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