Connect with us

Health

Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia | BMC Psychiatry

Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia | BMC Psychiatry

 


  • Hafner H, an der Heiden W. Epidemiology of schizophrenia. Can J Psychiatry. 1997;42(2):139–51.

    Article 
    CAS 

    Google Scholar
     

  • Chen XJ, Wang DM, Zhou HX, Zhu RR, Tian Y, Du YX, et al. Association of depressive symptoms with cognitive impairment in patients with never-treated first-episode schizophrenia: analysis of the Depression in Schizophrenia in China (DISC) study. Gen Hosp Psychiatry. 2021;71:108–13.

    Article 

    Google Scholar
     

  • Hoertel N, Jaffre C, Pascal de Raykeer R, McMahon K, Barriere S, Blumenstock Y, et al. Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: prevalence and associated factors in a multicenter study. J Affect Disord. 2019;251:60–70.

    Article 

    Google Scholar
     

  • Cohen CI, Ryu HH. A longitudinal study of the Outcome and Associated factors of Subsyndromal and Syndromal Depression in Community-Dwelling older adults with Schizophrenia Spectrum Disorder. Am J Geriatr Psychiatry. 2015;23(9):925–33.

    Article 

    Google Scholar
     

  • Maurice-Gelinas C, Deslauriers J, Monpays C, Sarret P, Grignon S. The 5alpha-reductase inhibitor finasteride increases suicide-related aggressive behaviors and blocks clozapine-induced beneficial effects in an animal model of schizophrenia. Physiol Behav. 2018;191:65–72.

    Article 
    CAS 

    Google Scholar
     

  • Harmer B, Lee S, Duong Tv H, Saadabadi A. Suicidal Ideation. StatPearls. Treasure Island (FL)2022.

  • Wang H, Lesh TA, Maddock RJ, Fassbender C, Carter CS. Delay discounting abnormalities are seen in first-episode schizophrenia but not in bipolar disorder. Schizophr Res. 2020;216:200–6.

    Article 

    Google Scholar
     

  • Sariaslan A, Larsson H, Fazel S. Genetic and environmental determinants of violence risk in psychotic disorders: a multivariate quantitative genetic study of 1.8 million swedish twins and siblings. Mol Psychiatry. 2016;21(9):1251–6.

    Article 
    CAS 

    Google Scholar
     

  • Wasserman D, Carli V, Iosue M, Javed A, Herrman H. Suicide prevention in psychiatric patients. Asia Pac Psychiatry. 2021;13(3):e12450.

    Article 

    Google Scholar
     

  • van Erp TG, Baker RA, Cox K, Okame T, Kojima Y, Eramo A, et al. Effect of brexpiprazole on control of impulsivity in schizophrenia: a randomized functional magnetic resonance imaging study. Psychiatry Res Neuroimaging. 2020;301:111085.

    Article 

    Google Scholar
     

  • Xu YM, Li F, Liu XB, Zhong BL. Depressive symptoms in chinese male inpatients with schizophrenia: prevalence and clinical correlates. Psychiatry Res. 2018;264:380–4.

    Article 

    Google Scholar
     

  • Fang X, Chen L, Wang D, Yu L, Wang Y, Chen Y, et al. Metabolic profiling identifies TC and LDL as potential serum biomarkers for depressive symptoms in schizophrenia. Psychiatry Res. 2019;281:112522.

    Article 
    CAS 

    Google Scholar
     

  • Miller BJ, McCall WV, Xia L, Zhang Y, Li W, Yao X, et al. Insomnia, suicidal ideation, and psychopathology in chinese patients with chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110202.

    Article 

    Google Scholar
     

  • Hoptman MJ. Impulsivity and aggression in schizophrenia: a neural circuitry perspective with implications for treatment. CNS Spectr. 2015;20(3):280–6.

    Article 

    Google Scholar
     

  • Barry AB, Koeppel JA, Ho BC. Impulsive decision making, brain cortical thickness and familial schizophrenia risk. Schizophr Res. 2020;220:54–60.

    Article 

    Google Scholar
     

  • Huang Z, Kang M, Li G, Xiong P, Chen H, Kang L, et al. Predictive effect of Bayes discrimination in the level of serum protein factors and cognitive dysfunction in schizophrenia. J Psychiatr Res. 2022;151:539–45.

    Article 

    Google Scholar
     

  • Dai N, Jie H, Duan Y, Xiong P, Xu X, Chen P, et al. Different serum protein factor levels in first-episode drug-naive patients with schizophrenia characterized by positive and negative symptoms. Psychiatry Clin Neurosci. 2020;74(9):472–9.

    Article 
    CAS 

    Google Scholar
     

  • Fernandes BS, Steiner J, Berk M, Molendijk ML, Gonzalez-Pinto A, Turck CW, et al. Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications. Mol Psychiatry. 2015;20(9):1108–19.

    Article 
    CAS 

    Google Scholar
     

  • Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci. 2003;4(4):299–309.

    Article 
    CAS 

    Google Scholar
     

  • D’Souza A, Dave KM, Stetler RA. Targeting the blood-brain barrier for the delivery of stroke therapies. Adv Drug Deliv Rev. 2021;171:332–51.

    Article 

    Google Scholar
     

  • Pandya CD, Kutiyanawalla A, Pillai A. BDNF-TrkB signaling and neuroprotection in schizophrenia. Asian J Psychiatr. 2013;6(1):22–8.

    Article 

    Google Scholar
     

  • Foltran RB, Diaz SL. BDNF isoforms: a round trip ticket between neurogenesis and serotonin? J Neurochem. 2016;138(2):204–21.

    Article 
    CAS 

    Google Scholar
     

  • Matsuda S, Ikeda Y, Murakami M, Nakagawa Y, Tsuji A, Kitagishi Y. Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses.Diseases. 2019;7(1).

  • Mohammadi A, Amooeian VG, Rashidi E. Dysfunction in brain-derived neurotrophic factor signaling pathway and susceptibility to Schizophrenia, Parkinson’s and Alzheimer’s Diseases. Curr Gene Ther. 2018;18(1):45–63.

    Article 
    CAS 

    Google Scholar
     

  • Yoo JM, Lee BD, Sok DE, Ma JY, Kim MR. Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells. Redox Biol. 2017;11:592–9.

    Article 
    CAS 

    Google Scholar
     

  • Guo C, Liu Y, Fang MS, Li Y, Li W, Mahaman YAR, et al. omega-3PUFAs improve cognitive impairments through Ser133 phosphorylation of CREB upregulating BDNF/TrkB Signal in Schizophrenia. Neurotherapeutics. 2020;17(3):1271–86.

    Article 
    CAS 

    Google Scholar
     

  • Zhang W, Song JK, Yan R, Li L, Xiao ZY, Zhou WX, et al. Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling. Acta Pharmacol Sin. 2018;39(8):1259–72.

    Article 
    CAS 

    Google Scholar
     

  • Martis LS, Wiborg O, Holmes MC, Harris AP. BDNF(+/-) rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders. Genes Brain Behav. 2019;18(2):e12546.


    Google Scholar
     

  • Fang X, Chen Y, Wang Y, Ren J, Zhang C. Depressive symptoms in schizophrenia patients: a possible relationship between SIRT1 and BDNF. Prog Neuropsychopharmacol Biol Psychiatry. 2019;95:109673.

    Article 
    CAS 

    Google Scholar
     

  • Han D, Sun D, Xiu M, Su X, Wang J, Li J, et al. Association between the improvement in depressive symptoms and serum BDNF levels in drug-naive first episode patients with schizophrenia: a longitudinal follow-up. Psychoneuroendocrinology. 2021;133:105392.

    Article 
    CAS 

    Google Scholar
     

  • Pasyk S, Sanger N, Kapczinski F, Samaan Z. Evaluation of BDNF as a Biomarker for Impulsivity in a Psychiatric Population. Diagnostics (Basel). 2020;10(6).

  • Beaulieu JM. A role for akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci. 2012;37(1):7–16.

    Article 

    Google Scholar
     

  • Palumbo S, Paterson C, Yang F, Hood VL, Law AJ. PKBbeta/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. Mol Psychiatry. 2021;26(2):411–28.

    Article 
    CAS 

    Google Scholar
     

  • Cadet JL, Brannock C, Jayanthi S, Krasnova IN. Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat. Mol Neurobiol. 2015;51(2):696–717.

    Article 
    CAS 

    Google Scholar
     

  • Aurelian L, Warnock KT, Balan I, Puche A, June H. TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation. Transl Psychiatry. 2016;6:e815.

    Article 
    CAS 

    Google Scholar
     

  • Yin F, Zhang J, Lu Y, Zhang Y, Liu J, Deji C, et al. Modafinil rescues repeated morphine-induced synaptic and behavioural impairments via activation of D1R-ERK-CREB pathway in medial prefrontal cortex. Addict Biol. 2022;27(1):e13103.

    Article 
    CAS 

    Google Scholar
     

  • Tripp A, Oh H, Guilloux JP, Martinowich K, Lewis DA, Sibille E. Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. Am J Psychiatry. 2012;169(11):1194–202.

    Article 

    Google Scholar
     

  • Xiao W, Liu H, Zhang H, Liu Q, Fu P, Chen J, et al. Reliability and validity of the chinese version of the Calgary Depression Scale for Schizophrenia. Aust N Z J Psychiatry. 2009;43(6):548–53.

    Article 

    Google Scholar
     

  • Lina. YM, Yi Y. Q, al. e. reliability and validity of the S-UPPS-P impulsive behavior scale in chinese schizophrenics. J Psychiatry. 2021;34:494–8. (in Chinese).


    Google Scholar
     

  • Stertz L, Di Re J, Pei G, Fries GR, Mendez E, Li S, et al. Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients. Neuropsychopharmacology. 2021;46(3):673–82.

    Article 
    CAS 

    Google Scholar
     

  • Nawwar DA, Zaki HF, Sayed RH. Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats. Inflammopharmacology. 2022;30(5):1891–907.

    Article 
    CAS 

    Google Scholar
     

  • Zhang QD, Y,W.Yang,C H. Expression of PI3K-AKT gene in peripheral blood and its correlation with clinical symptom in patients with schizophrenia. J Psychiatry. 2022;33:297–300. (in Chinese).


    Google Scholar
     

  • Liu L, Luo Y, Zhang G, Jin C, Zhou Z, Cheng Z, et al. The mRNA expression of DRD2, PI3KCB, and AKT1 in the blood of acute schizophrenia patients. Psychiatry Res. 2016;243:397–402.

    Article 
    CAS 

    Google Scholar
     

  • Howell KR, Floyd K, Law AJ. PKBgamma/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: relevance for schizophrenia. PLoS ONE. 2017;12(5):e0175993.

    Article 

    Google Scholar
     

  • Hong W, Zhao M, Li H, Peng F, Wang F, Li N, et al. Higher plasma S100B concentrations in Schizophrenia Patients, and Dependently Associated with inflammatory markers. Sci Rep. 2016;6:27584.

    Article 
    CAS 

    Google Scholar
     

  • Ai J, Sun LH, Che H, Zhang R, Zhang TZ, Wu WC, et al. MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci. 2013;33(9):3989–4001.

    Article 
    CAS 

    Google Scholar
     

  • Chadha R, Meador-Woodruff JH. Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia. Neuropsychopharmacology. 2020;45(6):1059–67.

    Article 
    CAS 

    Google Scholar
     

  • Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci. 2005;6(8):603–14.

    Article 
    CAS 

    Google Scholar
     

  • Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, et al. Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. J Neurosci. 2011;31(36):12963–71.

    Article 
    CAS 

    Google Scholar
     

  • Yeh CM, Huang CC, Hsu KS. Prenatal stress alters hippocampal synaptic plasticity in young rat offspring through preventing the proteolytic conversion of pro-brain-derived neurotrophic factor (BDNF) to mature BDNF. J Physiol. 2012;590(4):991–1010.

    Article 
    CAS 

    Google Scholar
     

  • Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol. 2000;10(3):381–91.

    Article 
    CAS 

    Google Scholar
     

  • Stoilov P, Castren E, Stamm S. Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism. Biochem Biophys Res Commun. 2002;290(3):1054–65.

    Article 
    CAS 

    Google Scholar
     

  • Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science. 2001;294(5548):1945–8.

    Article 
    CAS 

    Google Scholar
     

  • Upthegrove R, Marwaha S, Birchwood M. Depression and Schizophrenia: cause, Consequence, or Trans-diagnostic issue? Schizophr Bull. 2017;43(2):240–4.


    Google Scholar
     

  • Chen DC, Wang J, Wang B, Yang SC, Zhang CX, Zheng YL, et al. Decreased levels of serum brain-derived neurotrophic factor in drug-naive first-episode schizophrenia: relationship to clinical phenotypes. Psychopharmacology. 2009;207(3):375–80.

    Article 
    CAS 

    Google Scholar
     

  • Grover BNS. Depression in schizophrenia: prevalence and its impact on quality of life, disability, and functioning. Asian J Psychiatr. 2020;54:102425.

    Article 

    Google Scholar
     

  • Zhang C, Fang X, Yao P, Mao Y, Cai J, Zhang Y, et al. Metabolic adverse effects of olanzapine on cognitive dysfunction: a possible relationship between BDNF and TNF-alpha. Psychoneuroendocrinology. 2017;81:138–43.

    Article 
    CAS 

    Google Scholar
     

  • Faugere M, Micoulaud-Franchi JA, Faget-Agius C, Lancon C, Cermolacce M, Richieri R. High C-reactive protein levels are associated with depressive symptoms in schizophrenia. J Affect Disord. 2018;225:671–5.

    Article 
    CAS 

    Google Scholar
     

  • Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, et al. Brain-derived neurotrophic factor as a biomarker for cognitive recovery in acute schizophrenia: 12-week results from a prospective longitudinal study. Psychopharmacology. 2018;235(4):1191–8.

    Article 
    CAS 

    Google Scholar
     

  • Mosiolek A, Mosiolek J, Jakima S, Pieta A, Szulc A. Effects of Antidepressant Treatment on Neurotrophic Factors (BDNF and IGF-1) in Patients with Major Depressive Disorder (MDD). J Clin Med. 2021;10(15).

  • Fernandes BS, Dai Y, Jia P, Zhao Z. Charting the proteome landscape in major psychiatric disorders: from biomarkers to biological pathways towards drug discovery. Eur Neuropsychopharmacol. 2022;61:43–59.

    Article 
    CAS 

    Google Scholar
     

  • Armentero MT, Sinforiani E, Ghezzi C, Bazzini E, Levandis G, Ambrosi G, et al. Peripheral expression of key regulatory kinases in Alzheimer’s disease and Parkinson’s disease. Neurobiol Aging. 2011;32(12):2142–51.

    Article 
    CAS 

    Google Scholar
     

  • Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, et al. Quercitrin rapidly alleviated Depression-like Behaviors in Lipopolysaccharide-Treated mice: the involvement of PI3K/AKT/NF-kappaB signaling suppression and CREB/BDNF signaling restoration in the Hippocampus. ACS Chem Neurosci. 2021;12(18):3387–96.

    Article 
    CAS 

    Google Scholar
     

  • Platenik J, Fisar Z, Buchal R, Jirak R, Kitzlerova E, Zverova M, et al. GSK3beta, CREB, and BDNF in peripheral blood of patients with Alzheimer’s disease and depression. Prog Neuropsychopharmacol Biol Psychiatry. 2014;50:83–93.

    Article 
    CAS 

    Google Scholar
     

  • Bartolotti N, Bennett DA, Lazarov O. Reduced pCREB in Alzheimer’s disease prefrontal cortex is reflected in peripheral blood mononuclear cells. Mol Psychiatry. 2016;21(9):1158–66.

    Article 
    CAS 

    Google Scholar
     

  • Wang Y, Yin F, Guo H, Zhang J, Yan P, Lai J. The role of dopamine D1 and D3 receptors in N-Methyl-D-Aspartate (NMDA)/GlycineB site-regulated Complex Cognitive Behaviors following repeated Morphine Administration. Int J Neuropsychopharmacol. 2017;20(7):562–74.

    Article 
    CAS 

    Google Scholar
     

  • Sources

    1/ https://Google.com/

    2/ https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-04718-8

    The mention sources can contact us to remove/changing this article

    What Are The Main Benefits Of Comparing Car Insurance Quotes Online

    LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

    ExBUlletin

    to request, modification Contact us at Here or [email protected]