Health
Ghana Approves Oxford Malaria Vaccine
/cloudfront-us-east-2.images.arcpublishing.com/reuters/XD6GOSUDBBKVNJVQYUEJGEVCKI.jpg "Ghana Approves Oxford Malaria Vaccine")
LONDON (Reuters) – A malaria vaccine under close scrutiny from the University of Oxford is now available in Ghana as the African nation ramps up its efforts to combat a mosquito-borne disease that kills a child every minute. Got the first approval.
effort is one Several More than 600,000 people die each year, mostly African children. The complex structure and life cycle of the malaria parasite have long hindered vaccine development.
UK drugmaker GSK’s first malaria vaccine Moquirix after decades of work (GSK.L)which was approved by the World Health Organization (WHO) last year, lack of funds And commercial viability has hampered the company’s ability to produce as many doses as needed.
Oxford’s vaccine has secured regulatory approval in the age group most at risk of dying from malaria (children aged 5 to 36 months).
By contrast, GSK has committed to producing up to 15 million doses of Mosquirix each year until 2028, which the WHO says is needed in the long term to cover about 25 million children. This is well below the approximately 100 million doses of a four-dose vaccine per year.
intermediate data The results of an Oxford vaccine trial involving more than 400 infants were published in a medical journal in September.
Twelve months after the fourth dose, vaccine efficacy was 80% in the high-dose group and 70% in the low-dose adjuvant group of the vaccine’s immune-enhancing adjuvant component. The doses were administered prior to the peak malaria season in Burkina Faso.
Data from ongoing Phase III clinical trials enrolling 4,800 children in Burkina Faso, Kenya, Mali and Tanzania are expected to be published in medical journals in the coming months.
But late-stage data suggesting vaccine performance similar to Phase 2 trials has been shared with regulators over the past six months, said Oxford scientist Adrian Hill.
Childhood vaccines in Africa are typically funded by international organizations such as Gavi and UNICEF after being supported by the World Health Organization (WHO).
It’s the first time a major vaccine has been approved in an African country, and it predates wealthier countries, Hill added, adding that it’s unusual for African regulators to review the data earlier than the WHO. pointed out that
“Especially since COVID, regulators in Africa have taken a much more aggressive stance and they have said they… don’t want to be last in line.”
Reported by Natalie Glover, London.Edited by Kirsten Donovan
Our criteria: Thomson Reuters Trust Principles.
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Sources 2/ https://www.reuters.com/business/healthcare-pharmaceuticals/ghana-first-approve-oxfords-malaria-vaccine-2023-04-12/ The mention sources can contact us to remove/changing this article |
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