Health
Uses electrical stimulation to heal wounds 3x faster
Chronic wounds are a major health problem for diabetics and the elderly, and can even lead to amputation in extreme cases. Using electrical stimulation, researchers in a project at the Chalmers University of Technology in Sweden and the University of Freiburg in Germany have developed a method that speeds up the healing process and makes wounds heal three times faster.
A new study from Chalmers University of Technology and the University of Freiburg shows that wounds in cultured skin cells heal three times faster when stimulated with electrical current.The project recently received more funding so the research can move one step closer to the interests of the market and patients. Image Credit: Chalmers Institute of Technology
There is an old Swedish proverb that never ignores a small wound or a friend in need. For most people, small wounds do not lead to serious complications, but many common diagnoses make wounds much more difficult to heal. people with diabetes, spinal cord injury or poor circulation impair the ability to heal wounds. This means a higher risk of infections and chronic wounds, which can lead to serious consequences such as amputation in the long run.
Chalmers and a research group at the University of Freiburg have developed a method using electrical stimulation to accelerate the healing process.
“Chronic wounds are a big social problem that we don’t hear much about. It could be a game changer for people who often suffer from pneumonia,” said Chalmers Institute of Technology and project director of research.
Electrical induction of cells for faster healing
Researchers have based their work on the old hypothesis that electrical stimulation of damaged skin can be used to heal wounds. The idea is that skin cells are electrotactic. That is, the skin cells “move” directionally within the electric field. This means that when an electric field is applied to a petri dish containing skin cells, the cells stop moving randomly and start moving in the same direction. Researchers have investigated how this principle can be used to electrically induce cells to speed wound healing. Using a small designed chip, the research team was able to compare wound healing on artificial skin, stimulating one wound with electricity and allowing it to heal without electricity. The difference was noticeable.
We were able to use the old hypothesis of electrical stimulation to show that wound healing can be greatly accelerated. To study exactly how this works for wounds, we have developed a kind of biochip. I cultured skin cells on it and made a small scar on it. Then an electric field stimulated him one wound, and apparently he healed three times. It’s as fast as a wound heals without electrical stimulation. “
Maria Asplund, Associate Professor of Bioelectronics, Chalmers Institute of Technology
Hope for Diabetes Patients
in this study, Researchers also focused on wound healing associated with diabetes, a growing health problem worldwide. According to the World Health Organization (WHO) and the International Diabetes Federation, today 1 in 11 of her adults has some form of diabetes.
“We looked at wounds in a diabetic model to see if our method would still work in such cases. But with electrical stimulation, we can speed up the healing of diabetes-affected cells to more or less match healthy skin cells,” says Asplund.
The next step in personalized care
Chalmers researchers recently received a large grant. This will allow them to continue their research in this area and, in the long term, develop consumer wound healing products in the market. Similar products have come out before, but more basic research is needed to develop effective products that generate sufficient field strength and stimulate in the appropriate way for each individual. Now comes Asplund and her colleagues.
“We are currently investigating how different skin cells interact during stimulation to get one step closer to realistic wounds. We hope to develop a concept that can adapt stimulation based on increase.
sauce:
Journal reference:
Scherner, S. and others. (2023). Bioelectronic Microfluidic Wound Healing: A Platform for Investigating Direct Current Stimulation of Injured Cell Populations. lab-on-a-chip. doi.org/10.1039/D2LC01045C.
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