Health
In a staggering test, scientists revive damaged lungs for transplant
Dr. Marcelo Cypel, a lung transplant surgeon at the University of Toronto, said he had successfully resuscitated and transplanted 600 lungs over the past decade. But there is a limitation: the lungs can be maintained this way for only a few days, not for a few days. And few lungs can be rescued.
“The more time you have, the more time you have to repair the injury,” said Dr. Cypel. “Pneumonia can’t go away in 4 to 6 hours, but it can be done by maintaining the lungs for a few days.”
So Dr. Vunjak-Novakovic and his group decided that instead of creating a new lung, it might improve this method. It has become clear that not only the ventilator but also the body is necessary to restore the lungs, and it removes metabolic waste products and supplies necessary energy to maintain organs and restore health.
solution? A pig that supports the lungs as they recover. In animal studies, the researchers “breathed” the damaged pig lungs for four days, maintaining enough time to repair themselves, even the severely damaged lungs.
Scientists are finally ready to experiment with their methods using the human lungs. The six organs they received, wherever they were refused by the surgeon, were seriously damaged. After 6 hours of treatment with the original method of ventilation and nutrient solution, one had already failed to improve.
However, 24 hours after the surgery began, all six lungs appeared bright pink and healthy. Laboratory tests have shown that the lung cells have recovered.
“The pig was able to keep its lungs alive and repair itself,” said Dr. Vachetta.
Researchers say porcine blood offers both advantages and disadvantages over human patients. For example, patients on the lung transplant list may be very ill and intolerant of having a large tube in their neck.
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