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Approximately 60% of the intestinal phylum varies seasonally from morning to night

Approximately 60% of the intestinal phylum varies seasonally from morning to night

 


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Zarrinpar A, et al. Abstract 395: The human gut microbiota exhibits diurnal and seasonal rhythmic patterns. Presented at: Digestive Disease Week. May 6-9, 2023. Chicago (Hybrid).

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balance of microbes in the human gut Diurnal and seasonal changes have been reported, with the most pronounced microbiome fluctuations from summer to winter.

“The microbiome makes up about half of the cells that make up humans, and variations in the composition of the microbiome can have wide-ranging implications for health and medicine.” Amir ZarinpalMD, PhD, An assistant professor of medicine at the University of California, San Diego said in a media briefing for Gastroenterology Week: “our intestinal flora, Always changing, but very dynamic.

Studies show diurnal signals at different taxonomic levels, with nearly 60% of phyla fluctuating in 24 hours.

Data obtained from Zarrinpar A et al. Abstract 395: The human gut microbiota exhibits diurnal and seasonal rhythmic patterns. Presented at: Digestive Disease Week. May 6-9, 2023. Chicago (Hybrid).

“My team and I set out to learn more about how variations in the gut microbiota throughout the day and across seasons affect health and disease.”

Using data from the global American Gut Project, Zarrinpar and colleagues identified 19,335 adult stool samples and analyzed the time, date, and location of collection. They reported diurnal signals present at different taxonomic levels, with distinct 24-h cycling in nearly 60% of phyla.

A notable example is actinomycete, Researchers identified lower levels in fecal samples taken in the morning compared to samples taken later in the day. Zarrinpar and colleagues did not identify the cause of these daily fluctuations, but hypothesized that diet and sleep were the main culprits.

Seasonal changes are “even more pronounced,” Zarrinpar said, with certain types of bacteria following one of two distinct patterns throughout the year.For example, researchers may Proteobacteria Levels rise steadily in winter, rising in spring and peaking in summer. Research is ongoing, but Zarrinpar explained that the data suggests latitude, climate, humidity and environmental factors may play a role.

“These findings provide important insight into the role of altered gut microbiota in health and disease,” concluded Zarrinpar. “They could explain why we are more prone to seasonal diseases and whether our microbiome prepares us to do so. Not only that, but how researchers study the microbiome.” and how our research can be impacted by these fluctuations in the microbiome.”

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