Health
Drugs that calm an overactive immune system reduce mortality risk by 45% in severe COVID-19 patients
Key Point
- Cytokine storm may cause death in severe COVID-19 patients
- Study: Drugs that Prevent Cytokine Storms Help Reduce Coronavirus Death
- A single dose of a drug given intravenously within 1 day of intubation was strange
Severely ill COVID-19 patients are 45% less likely to die because they have been given drugs that help calm the overreactive immune system, a new study reported.
The drug also helped patients with COVID-19 to be discharged and have their ventilators withdrawn earlier.
Experts at the University of Michigan have found that declining mortality in severe COVID-19 patients occurs even when these patients double the risk of developing infections other than those caused by the novel coronavirus. did. They emphasized the fact that quenching the storm of cytokines can bring great benefits to patients.
Cytokines are proteins that regulate cells in the human immune system. Cytokine storms occur when the body has a severe immune response that releases large amounts of cytokines rapidly. It can be very harmful to host cells. Experts believe that the cytokine storm may be one of the leading causes of death in patients with severe COVID-19.
COVID-19 An immune system sedative that appears promising for treatment-tocilizumab.
When given intravenously, the drug tocilizumab, originally designed to treat rheumatoid arthritis and advertised to quench the overreactive immune system, helps reduce the risk of death in COVID-19 patients.
After analyzing the data of 154 patients with severe coronavirus treated in the early stages of the pandemic at UM’s academic medical center, Michigan Medicine, researchers were able to conclude that the drug showed promise.
At the time, there was not enough information to help COVID-19 patients on ventilator support. Fifty percent of these patients received the drug, but the other half did not. It was administered within 24 hours after intubation.
This natural opportunity to compare the results of the two groups led to this observational study. However, clinical trials are still needed to support the findings of the study.
“One of the roles of epidemiology is to rigorously assess real-world data on treatment efficacy, especially when evidence from clinical trials is not available. I’ve been trying to prove my mistakes. These data are partly due to concerns about drug delivery to other patients.” MHealth Lab Lead researcher and epidemiologist Dr. Emily Somers, Sc.M. Was quoted.
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