Connect with us


An mRNA vaccine that programs the body to fight pancreatic cancer shows early promise

An mRNA vaccine that programs the body to fight pancreatic cancer shows early promise



When Barbara Brigham was diagnosed with pancreatic cancer in September 2020, the odds weren’t in her favor.

Pancreatic cancer is one of the deadliest malignancies, with 88% of patients dying. It is also one of the most difficult to treat. The tumor can be surgically removed, but in 90% of patients he will recur within 7-9 months. Chemotherapy helps prolong life but is rarely curative. Radiation, immunotherapy, and targeted therapy are also ineffective.

Today, nearly three years after his diagnosis, Brigham says routine scans found no trace of cancer in his pancreas. She credits an treatment being tested by BioNTech, one of the companies that helped produce an mRNA vaccine for Covid-19: a personalized cancer vaccine.

Brigham was one of 16 participants in a recent test of this new technology.The results of the research published on wednesday in the journal Nature.

Of the 16 patients who were able to complete all phases of the study, 8 responded to the vaccine, teaching their immune system how to recognize and fight off cancer cells. None of these eight patients had cancer recurrence.

Blood tests showed that all eight responders generated T cells against their tumors, and they persisted for at least two years despite a follow-up course of chemotherapy.

Of the eight patients who had an inadequate response to the vaccine, only two never had their cancer come back.

“I think it’s really promising,” said Dr. Niha Zaidi, an oncologist at Johns Hopkins Kimmel Cancer Center, who was not involved in the new study.

“We don’t know that yet, but it’s certainly a very exciting interim result,” she said.

This study was not designed to test whether the vaccine is effective. The researchers primarily set out to see if the treatment was safe and viable. I wanted to

Researchers were looking for a correlation between whether a vaccine works and whether it confers clinical benefit. Sometimes drugs do what they’re meant to do, but for some reason they don’t treat the disease.

“I definitely think it’s very encouraging to see that [an immune] Response correlates with recurrence-free survival. However, this is a small study, with only 16 of his patients in Phase 1. So it’s compatible. It is not causal. We need to verify causality in large clinical trials,” said Vinod Balachandran, M.D., a cancer surgeon at Memorial His Sloan Kettering Cancer Center who led the study.

He says plans for the study are already underway.

In this first study, doctors surgically removed the patient’s tumor, sent the tissue to a German laboratory, and scientists sequenced the genetic code from the tumor and the patient’s blood. They compared these gene sets to find what changed in cancer cells. After identifying the altered genes, they ran a computer program to select the most effective targets.

Then they made a personalized mRNA vaccine. The patient received eight doses that were injected into the bloodstream rather than injected into the muscle like the COVID-19 vaccine. That’s because the researchers were trying to stimulate a slightly different part of the immune system.

“The type of immune response we want to elicit is slightly different than the type of immune response we want to elicit against viruses, mostly antibody responses, and in the case of cancer, we’re actually trying to elicit a T-cell response.” Balachandran said. He said.

Blood circulates through the lymphatic system, where lymphoid organs such as lymph nodes and the spleen help generate T cells.

After eight doses of what Brigham called “immune,” the patient underwent six months of chemotherapy. Then they got the final booster of the vaccine.

“It wasn’t easy to get over. It was a little tough,” said Brigham. She tolerated the vaccinations fairly well, but she went to the hospital twice during chemotherapy.

She now has scans every three months to check her pancreas, and so far the cancer has not returned.

However, not all participants did as well as she did. The other eight did not develop the proper pool of programmed T cells to respond to the vaccine, but the researchers have a theory as to why.

According to Balachandran, there are two main types of surgery for pancreatic cancer. One is to remove the spleen along with the tumor.

The mRNA vaccine was found to be concentrated in the spleen. This appears to be important in developing a large pool of tumors that attack T cells.

When the researchers administered the vaccine to mice that had had their spleens removed, they did not respond as well as mice with intact spleens.

Balachandran said seven of the study participants had their spleens removed, five of whom were in the group that did not respond well to the vaccine. It wasn’t statistically significant, but notes that a larger trial might show a difference.

“So this is our current working hypothesis,” he said.

Brigham said she was just grateful to be able to participate.

“I’m just grateful that I was accepted,” said the 77-year-old. She recently got to see her oldest grandson graduate from college. She never thought she would live to see the moment.

“The chance and timing were perfect. It helped me, and I hope it helps someone else.”




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]