Health
Early detection of Parkinson’s disease by alpha-synuclein amplification assay: Russell Lebovitz, MD, PhD
Watch time: 6 minutes
“The idea that we can suddenly discover the cause of these diseases and do it years before symptoms appear is hope for patients. Because, unfortunately, brain damage is serious and in most cases irreversible, management of these diseases requires early detection and early treatment. and even if it is already underway, it is almost preventive.”
In 2019, the FDA granted Amplion Breakthrough Device designation to use the SYNTap biomarker test to assist diagnosis. Parkinson’s disease This test is a first-in-class qualitative research and development test (LDT) and the only seed amplification assay useful for diagnosing PD, Lewy bodies and other synucleinopathies.dementia (LBD), and Alzheimer’s disease (AD) Lewy body variant.1
Andrew Sideloweuf, M.D., Ph.D., director of the Center for Parkinson’s Disease and Movement Disorders at the University of Pennsylvania and co-principal investigator of the Parkinson’s Progression Markers Initiative (PPMI), recently delivered an oral presentation at a lecture in the United States. 2023 American Academy of Neurology (AAN) Annual Meeting, April 22-27 in Boston, Massachusetts. In his presentation, Mr. Siderowf explained how his alpha-synuclein seed amplification assay from Amprion was used in a landmark experiment. Recently Published PPMI Papers.
At the conference, Amprion CEO and co-founder Russell Lebowitz, M.D., said: neurology liveIn an interview, ® provided background on how the SYNTap assay was developed and this technique in diagnosing neurodegenerative diseases such as PD by detecting aggregates of misfolded α-synuclein in cerebrospinal fluid. explained the importance of Lebowitz also discussed how early detection of neurodegenerative diseases using Amprion’s technology can contribute to drug and clinical trial development.
Click here for more information on AAN 2023.
References
1. At the 2023 AAN Annual Meeting, Amplion will present the results of its research on the use of the Alpha-Synuclein Seed Amplification Assay in recent Parkinson’s disease research. news release. Published April 21, 2023. Accessed May 10, 2023. Recent Parkinson’s Amplification Assay -2023-aan-annual-meeting-301804312.html?tc=eml_cleartime
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