‘Forms’ of metabolically healthy and unhealthy obesity are associated with increased risk of obesity-related cancers

The new study will be presented this week at the European Obesity Conference (May 17-20) in Dublin, Ireland. National Cancer Institute Journal show that both metabolically healthy and unhealthy obesity ‘forms’ are associated with increased risk of various obesity-related cancers, with stronger associations in metabolically unhealthy obesity. I’m here. The research is by Dr. Ming Sun and his colleagues at Lund University in Malmö, Sweden.

Few studies have investigated how obesity with metabolic complications (commonly called metabolically unhealthy obesity) or uncomplicated obesity (healthy obesity) is associated with cancer.
In this new study, the authors found that body mass index (BMI, normal/overweight/obese) and metabolic health were associated with obesity-related cancer risk (n=23,630) in 797,193 Europeans. The interaction with states was jointly investigated.

A metabolic score consisting of blood pressure, plasma glucose and triglycerides (blood fat) was used to define metabolically healthy and unhealthy states, and statistical modeling was used to estimate the relationship.

Participants were therefore grouped into six different categories. Metabolic unhealthy obesity (6.8% of participants). Metabolic Healthy Obese (3.4%), Metabolic Unhealthy Overweight (15.4%), Metabolic Healthy Overweight (19.8%), Metabolic Unhealthy Normal Weight (12.5%), Metabolic Healthy normal weight (42.0%).

Metabolically unhealthy obesity is associated with obesity-related cancers, colon, rectal, pancreatic, endometrial, liver and gallbladder cancers compared to metabolically healthy normal weight. It was associated with an increased relative risk of cancer, renal cell carcinoma, with the highest risk estimates for endometrial cancer. , liver cancer, renal cell carcinoma (2.5- to 3.0-fold increased risk).

Among women, compared with metabolically healthy normal weight women, metabolically unhealthy obese women had a 21% risk of colon cancer, three times the risk of endometrial cancer, and a threefold risk of kidney cancer. 2.5 times increased risk. A metabolically healthy obese woman had a 2.4-fold increased risk of endometrial cancer and an 80% increased risk of kidney cancer, although the association with colon cancer was not statistically significant. died.

Among men, compared with metabolically healthy normal-weight men, metabolically unhealthy obese men had a 2.6-fold increased risk of kidney cancer, an 85% increased risk of colon cancer, and pancreatic and rectal cancer. increased risk of both cancers by 32%. In metabolically healthy obese men, his risk of kidney cancer increased by 67% and his risk of colon cancer increased by 42%, but the association with both pancreatic and rectal cancer is no longer statistically significant. In a rare finding, both metabolically healthy and unhealthy overweight (not obese) men had an approximately 50% increased risk of multiple myeloma, a blood cancer, whereas metabolically healthy men had an approximately 50% increased risk of multiple myeloma. Neither men nor unhealthy obese men had an increased risk of this cancer.

The authors suggest that in men only, obesity and metabolic complications increase the risk of these obesity-related cancers beyond what would be expected from the individual sum of each risk factor. It has said. “This has important public health implications, targeting the coexistence of metabolic problems and obesity, particularly obesity-related cancers in men, potentially preventing a significant number of cancer cases,” the researchers said. It suggests sexuality,” he said.

“This study highlights the importance of metabolic obesity phenotypic type in assessing obesity-related cancer risk. In general, being metabolically unhealthy is associated with Obesity-related cancer risks are further increased, suggesting that both obesity and metabolic status are useful targets.” For the prevention of obesity-related cancers. “