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NIH Enrolls Volunteers in Early-Phase Trial of mRNA-Based Universal Influenza Vaccine

NIH Enrolls Volunteers in Early-Phase Trial of mRNA-Based Universal Influenza Vaccine



The National Institutes of Health is currently enrolling participants in an trial. universal influenza vaccine We use mRNA technology.

The NIH is recruiting 50 volunteers, ages 18 to 49, for a Phase 1 trial at Duke University in Durham, North Carolina.

“A universal flu vaccine would be a major public health achievement that could eliminate the need to develop a seasonal flu vaccine each year, or eliminate the need for patients to receive annual flu vaccinations,” said NIAID Acting Director Hugh Oh. Dr. Chincross said.and news release. “In addition, some influenza viruses have significant pandemic potential. Universal influenza vaccines may serve as an important line of defense against the spread of future influenza pandemics.”

This early-stage trial will evaluate the optimal dose of an vaccine, comparing its immunogenicity and safety to current seasonal influenza vaccines. Participants in the trial will be followed for up to 1 year after vaccination, primarily to follow not only its safety but also its efficacy.

Between 2010 and 2020, influenza caused between 140,000 and 710,000 hospitalizations and between 12,000 and 52,000 deaths each year. U.S. Centers for Disease Control and Prevention.

There are several generic influenza vaccines in various stages of development and testing. The vaccine uses the same mRNA technology used in Pfizer’s and Moderna’s COVID-19 vaccines, but scientists first began experimenting with it after the first coronavirus. It was 2017, years before infectious disease vaccination.




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