Health
Fenofibrate Can “Downgrade” Covid-19 Threat to Common Cold Levels: Researcher
JERUSALEM: Fenofibrate, a widely used anti-cholesterol drug, can “reduce” the level of coronavirus risk to normal cold levels, scholars at the Hebrew University (HU) said in infected human tissues. Insisted after testing.
Professor Yaakov Nahmias, Head of HU’s Grass Center for Bioengineering, said in a joint study with Benjamin ten Oever of Mount Sinai Medical Center in New York. Coronavirus It is malicious because lipids deposit in the lungs and fenofibrate can reverse the damage.
“If our findings are corroborated by clinical studies, this set of treatments can reduce the severity of COVID-19 to as bad as a common cold,” Nahmias said in a press release issued by HU. Was quoted as saying.
Two researchers focused on how SARS-CoV-2 alters a patient’s lungs to reproduce itself.
They have found that the virus prevents the normal burning of carbohydrates. As a result, large amounts of fat accumulate in lung cells, a condition required for the virus to reproduce.
“This new understanding of SARS CoV-2 may help explain why patients with high blood sugar and cholesterol levels are at particularly high risk of developing COVID-19,” they said.
“A virus is a parasite that lacks the ability to replicate on its own, helping control cells and accomplishing their tasks. By understanding how SARS-CoV-2 regulates metabolism, you control it from the virus. You can recapture and rob the virus from the very resources needed to survive.”
Based on this conclusion, two researchers have begun screening for FDA-approved drugs that interfere with the ability of the virus to replicate. In their laboratory, the cholesterol-lowering drug fenofibrate, marketed under the Tricor brand, has shown very promising results.
By allowing lung cells to burn more fat, fenofibrate disrupts the viral grip on these cells and interferes with the fertility of SARS CoV-2. In fact, the researchers claim that the virus disappeared almost completely 5 days after treatment.
“The results of these studies could not come at a better time due to the surge in second wave infections around the world,” Nahmias said, “global cooperation may provide treatment. I don’t know.”
“The collaboration between Nahmias and tenOever labs shows the power of adopting an interdisciplinary approach to study SARS-CoV-2, and our findings help reduce the global burden of COVID-19. It can make a huge difference,” added tenOever.
There are many international efforts currently under development, Coronavirus vaccineResearch suggests that the vaccine may only protect patients for months, according to a university press release.
Therefore, blocking the functioning of the virus, rather than disabling it’s ability to attack first, could be the key to altering the COVID-19 table, he added.
Findings will be published this week at Cell Press’s Sneak Peak.
This story was published from the wire transfer feed with no changes to the text. Only the headline has changed.
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