Health
Hebrew University Professor-New Indian Express
JERUSALEM: Fenofibrate, a widely used anti-cholesterol drug, can “reduce” the level of coronavirus risk to normal cold levels, scholars at the Hebrew University (HU) said in infected human tissues. Insisted after testing.
YA Professor Yaakov Nahmias, Head of Grass Center for Bioengineering at HU, collaborated with Benjamin ten Oever at Mount Sinai Medical Center in New York to build up lipids in the lungs and restore fenofibrate to the new I found that the coronavirus is very malicious damage.
“If our findings are corroborated by clinical studies, this set of treatments can reduce the severity of COVID-19 to as bad as a common cold,” Nahmias said in a press release issued by HU. Was quoted as saying.
Two researchers focused on how SARS-CoV-2 alters a patient’s lungs to reproduce itself.
They have found that the virus prevents the normal burning of carbohydrates.
As a result, large amounts of fat accumulate in lung cells, a condition required for the virus to reproduce.
“This new understanding of SARS CoV-2 may help explain why patients with high blood sugar and cholesterol levels are at particularly high risk of developing COVID-19,” they said.
“A virus is a parasite that lacks the ability to replicate on its own, helping control cells and accomplishing their tasks. By understanding how SARS-CoV-2 regulates metabolism, you control it from the virus. You can recapture and rob the virus from the very resources needed to survive.”
Based on this conclusion, two researchers have begun screening for FDA-approved drugs that interfere with the ability of the virus to replicate.
In their laboratory, the cholesterol-lowering drug fenofibrate, marketed under the Tricor brand, has shown very promising results.
By allowing lung cells to burn more fat, fenofibrate disrupts the viral grip on these cells and interferes with the fertility of SARS CoV-2.
In fact, the researchers claim that the virus disappeared almost completely 5 days after treatment.
“The results of these studies could not come at a better time due to the surge in second wave infections around the world,” Nahmias said, “global cooperation may provide treatment. I don’t know.”
“The collaboration between Nahmias and tenOever labs shows the power of adopting an interdisciplinary approach to study SARS-CoV-2, and our findings help reduce the global burden of COVID-19. It can make a huge difference,” added tenOever.
There are many ongoing international efforts to develop a coronavirus vaccine, but research suggests that the vaccine may protect patients for only a few months, a university press release. Said.
Therefore, blocking the functioning of the virus, rather than disabling it’s ability to attack first, could be the key to altering the COVID-19 table, he added.
Findings will be published this week at Cell Press’s Sneak Peak.
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