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Clinical trials show Moderna COVID-19 vaccine is on the right track

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Within 12 hours after receiving the second dose of Experimental COVID-19 vaccine Developed by Moderna, Ian Haydon began to feel the chills. After that, nausea, headache, muscle aches and delirium occurred. His body temperature was 103.2 degrees.

At the age of 29, living in Seattle, one of the 45 participants in the company’s Phase I clinical trial knew his body was trying to protect against the vaccine. If it works, his immune system is prepared to fight a real coronavirus infection.

An avid marathon runner with no health problems, Haydon could not recall feeling the disease. His girlfriend took him to urgent care. Later that night he fainted in their apartment.

Symptoms faded with water and rest. One and a half days after shooting, he felt better.

Similar side effects of Moderna’s COVID-19 vaccine include: To report Published Tuesday by The New England Journal of Medicine. The results of the survey Notice In May the candidate vaccine stimulated the production of coronavirus antibodies in human testers.

The results of the peer-reviewed study are “promising and these support the ongoing development of this vaccine,” wrote Dr. Penny Heaton of the Bill & Melinda Gates Institute of Medicine. editorial For the journal. “But we must keep in mind the complexity of vaccine development and the work to be done before the COVID-19 vaccine becomes widely available.”

Moderna is a global leader in developing vaccines and controlling the COVID-19 pandemic. The 10-year-old company in Cambridge, Massachusetts is one of six candidates to receive funding as part of that. Operation warp speedA multi-billion dollar federal initiative designed to accelerate vaccine development.

The vaccine reacts by introducing the genetic material of the coronavirus into the body, producing proteins in the body that allow the virus to invade host cells. The presence of that so-called spike protein triggers the body’s immune response, triggering the development of protective antibodies that can stop the virus along that pathway.

This technique, known as mRNA, was first developed to combat other coronaviruses (MERS and SARS), but has not progressed beyond early clinical trials.

In the new Phase 1 trial, Haydon and other study subjects produced levels of coronavirus antibodies comparable to those who recovered from COVID-19. But that does not necessarily mean that the vaccine can provide immunity to the disease.

“This is the first step, but it’s an exciting first step,” he said. Dr. William Schaffner, An infectious disease specialist at Vanderbilt University, and a medical director at the National Infectious Diseases Foundation. “We have shown that this new technology—mRNA—can elicit a substantial immune response. I believe that the immune response correlates with future protection.”

Dr. Paul OfitA vaccine specialist at the Children’s Hospital of Philadelphia, he was more measured in his assessment.

“It was a small dose range trial that showed that the vaccine dose was safe and elicited a neutralizing antibody response similar to natural infection,” he said. “But a large phase 3 trial is needed.”

Moderna has recently finished enrolling candidates for Phase 2 trials. Phase 3 trials will begin later this month.

During the Phase 1 safety trial, the vaccine was administered in doses of 3 (25 micrograms, 100 mcg and 250 mcg) to 3 groups of 15 people. Men and women lived in Seattle and Atlanta and were 28 to 41 years old.

The research author is Dr. Lisa Jackson “No serious adverse events” or hospitalizations were reported at Kaiser Permanente Washington Health Institute in Seattle, and each group of candidates experienced significantly worse side effects after the second dose.

Such side effects are not uncommon, Schaffner said citing the shingles vaccine.

If the Moderna vaccine becomes widely used, “I need to tell everyone in advance that my arms may hurt and I’ll be sick for about a day. These conditions are: This also needs to be taken into account, as it can mimic the flu and COVID itself.”

The symptoms of 3 people who took 250 micrograms were rated as “severe”. Moderna did not administer a dose of 250 micrograms in the study.

Moderna One of many biotechnology companies The coronavirus vaccine is a top priority and investors are rewarding it. The company’s stock rose from $18.59 on February 24, when it announced it was pursuing a vaccine, to $75.04 at the end of the market on Tuesday. After the release of the survey, overtime trading rose another $ 12.06 to $ 87.10.

With an ambitious goal of producing 300 million vaccines by January, operation warp speed Challenge logistics.. Even if the vaccine proves effective against COVID-19, it will be difficult to produce and distribute.

“Remember that on the first day there aren’t enough vaccines across the United States,” Schaffner said. “When vaccines become more available, and for the long term many of the US population remain unvaccinated, we deploy vaccine programs. We must continue our social distance efforts. I won’t.”

Haydn, who received 250 mcg, slowly resumed his normal routine as Modelna advanced a new stage in the trial. He started marathon training again hoping to run his first race by the end of this year, and he will take his blood regularly to measure the levels of antibodies.

But he doesn’t take any chance. He is still wearing a mask, mostly inside, washing his hands “like a maniac.”

“I don’t feel protected,” he said. “What I’m worried about is actually less exposed than before. What if I catch a full-blown COVID? I think the hope for this vaccine will fall sharply .”

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