Health
Study Reports Common Genetic Underpinnings of Cannabis Use and Mental Illness
A new study from the University of Oslo was published in The Lancet Psychiatryreported a common genetic basis for cannabis use and psychiatric disorders such as schizophrenia and bipolar disorder. These findings may indicate that parts of the population are at increased risk for both cannabis use and mental illness, based on genetic predisposition.
There has been much debate about the relationship between cannabis use and psychiatric disorders. Cannabis is a psychoactive drug and can cause psychotic-like symptoms in some cases. Additionally, cannabis use is high among patients with psychotic-related disorders, such as schizophrenia and bipolar disorder.
Genetic factors play an important role in determining an individual’s susceptibility to developing psychiatric disorders and likelihood of cannabis use. Some genetic variants associated with cannabis use have also been associated with mental illness.
This recent study was led by Dr. et al. Weiqiu Cheng and Nadine Parker provide evidence that common genetic factors underlie this relationship.
This study shows that there is a common genetic basis underlying both cannabis use and our susceptibility to certain mental illnesses. These findings may indicate that parts of the population are at increased risk for both cannabis use and mental illness, based on genetic predisposition. ”
Weiqiu Cheng, first author
This study uses advanced statistical modeling to show that most common mutations increase the risk of both cannabis use and the development of schizophrenia or bipolar disorder. Still, there are some genetic variants with opposing effects that increase the risk of cannabis use while lowering the risk of the two psychiatric disorders, suggesting a complex relationship.
“These findings indicate that the complex associations between cannabis use and these disorders can be driven not only by cannabis use itself, but also by shared genetic susceptibility. It’s important because it’s important,” says researcher Nadine Parker.
Cannabis is used medicinally in some parts of the world as a pain reliever and as an antidepressant. Also, one component of cannabis is being investigated as a potential treatment for psychosis. “Common genetic variants with opposing effects may suggest the existence of biological mechanisms underpinning the beneficial effects of cannabis,” the researchers note.
These new findings have some important clinical implications. First, this information may lead to personalized care, including preventive and interventional measures for high-risk individuals. This could include reducing cannabis use in individuals at high genetic risk for schizophrenia and bipolar disorder. Second, future studies investigating the biological impact of common genetic mutations may contribute to the development of more targeted therapeutic efforts. Finally, improved knowledge of gene duplications will help stratify patients for more specialized treatment regimens.
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Reference magazines:
Chen, W. other. (2023) Relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study. Lancet Psychiatry. doi.org/10.1016/S2215-0366(23)00143-8.
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