Health
Blood samples may predict kidney disease in people with type 2 diabetes: study, ET HealthWorld
Washington: A. conceptual framework Created by researchers to predict whether a person has the following diseases: type 2 diabetes may develop renal injury.
This study was published in a journal.Nature Communications‘.Help your doctor prevent or ameliorate manage kidney disease among people with type 2 diabetes.
“This study provides a glimpse into the powerful future of predictive diagnostics,” said co-senior author Kevin Yip, PhD, professor and director of bioinformatics at Sanford Burnham Prebys. “Our team has demonstrated that by combining clinical data with cutting-edge technology, we can develop a computational model that will help a clinician optimize the treatment of her type 2 diabetes to prevent kidney disease. Did.”
Diabetes is the leading cause of kidney failure worldwide. Diabetes is responsible for 44% of end-stage renal disease and dialysis cases in the United States. In Asia, the figure is 50%.
“There have been great strides in developing treatments for kidney disease in people with diabetes,” said co-senior author Ronald Ma, MB BChir, FRCP, Professor of Medicine and Therapeutics, The Chinese University of Hong Kong. “However, it can be difficult to assess an individual patient’s risk of developing kidney disease based on clinical factors alone, so determining who is most at risk of developing diabetic kidney disease is an important clinical challenge. It’s a higher need.”
A new algorithm is based on the measurement of a process called DNA methylation. This process occurs when subtle changes accumulate in the DNA. DNA methylation can encode important information about which genes are turned on or off and is easily measured by blood tests.
“Our computational model can predict both current and future kidney function using methylation markers from blood samples. It means it can be easily implemented in parallel with current methods,” he says. yes.
Researchers developed the model using detailed data from over 1,200 people with type 2 diabetes registered in the Hong Kong Diabetes Registry. They also tested the model on another group of her 326 Native Americans with type 2 diabetes. This helped confirm that their approach could predict kidney disease in different populations.
“This study highlights the unique strengths of the Hong Kong Diabetes Registry and its enormous potential to drive further discoveries to improve our understanding of diabetes and its complications,” said study co-author Juliana of FRCP. Chan, M.D., said: She holds a PhD in Medicine and Therapeutics from the Chinese University of Hong Kong. Over 20 years ago she established the Hong Kong Diabetes Registry.
“The Hong Kong Diabetes Registry is a treasure of science,” added lead author Dr. Kelly Yichen Lee, a postdoctoral fellow at Sanford Burnham Prebys. “They have been following patients for years, which gives them a complete picture of how the health of people with diabetes can change over decades.”
Researchers are currently working to refine the model further. They are also extending the approach to examine other questions of human health and disease, such as figuring out why some cancer patients do not respond well to certain treatments.
“While the science is still developing, we are working to incorporate additional information into our models to further enhance precision medicine in diabetes,” added Ronald Mahr.
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