Microbiota-induced inflammation may lead to early-onset gestational diabetes

Source/disclosure information Issuer: Disclosure: The authors report no relevant financial disclosures. Add Topics to Email Alerts Get an email when new articles are posted Enter your email address to receive an email when new articles are posted. . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio Important points:Researchers have identified a precursor to gestational diabetes that originates from the gut microbiota.Gestational diabetes mellitus can be identified early in the first trimester of pregnancy. intestinal microbiota disorders reported that the resulting inflammation may be involved in the development of gestational diabetes from early in the first trimester of pregnancy. intestine."recognition of" women at risk of pregnancy In early pregnancy diabetes, specific recommendations on disease prevention may be possible now through lifestyle modifications, and perhaps in the future through specific pre-, pro-, and post-biotic supplements. ” omly corn, Master's degree, PhD, The lead author of the study and a professor of medicine at Bal-Ilan University in Israel said in a related press release: "Our findings suggest that increased inflammation caused by microbial dysbiosis triggers GDM. Future studies based on our findings will elucidate the underlying mechanisms." may help.” drive around KorenMaster's degree, PhD, wrote a colleague. image: adobe stock Noting the increasing incidence of gestational diabetes mellitus (GDM) worldwide, Koren et al. sought to better understand its pathophysiology and provide early prediction through the identification of GDM biomarkers in the first trimester (T1) of pregnancy. endeavored to expand its efforts.A prospective cohort study enrolled 394 pregnant women aged 18 to 40 years and assessed gut microbiota, metabolome, inflammatory cytokines, nutrition, and clinical records before diagnosis of GDM. The researchers then built a model that predicted the onset of GDM weeks before it was "usually diagnosed."During the second trimester of pregnancy, 11% of the cohort developed GDM, the remaining women did not serve as controls.According to the researchers, women diagnosed with GDM had common risk factors such as older maternal age and pre-pregnancy BMI, as well as the pro-inflammatory cytokines interleukin-4, IL-6, There were common risk factors such as increased levels of IL-8 and granulocyte-macrophage colony stimulation. factor and tumor necrosis factor. The researchers also reported reduced levels of the short-chain fatty acids isovaleric acid and isobutyric acid in the faeces of GDM patients.The researchers initially reported no significant differences in T1 gut microbiome composition between the GDM group and the healthy cohort, but after adjusting for age and BMI, women in the GDM group found 15 bacteria Species were found to be underestimated, especially the abundance of bacteria was low. Prevotella."We found broad and consistent evidence that GDM pathology begins as early as T1 in a large prospective cohort of pregnant women," Koren et al. conclude. "Furthermore, we successfully demonstrated that the precursors of GDM are derived from the gut microbiota and that early-onset GDM carries bacterial signatures responsible for at least some of the GDM phenotype."The researchers continued, "Our findings suggest that increased inflammation caused by microbial gut microbiota dysbiosis triggers GDM." Future studies based on our findings may help elucidate the underlying mechanisms. ”reference: Add Topics to Email Alerts Get an email when new articles are posted Enter your email address to receive an email when new articles are posted. . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio Microbiome Resource Center Sources 1/ https://Google.com/ 2/ https://www.healio.com/news/gastroenterology/20230526/microbiotainduced-inflammation-may-trigger-earlyonset-gestational-diabetes The mention sources can contact us to remove/changing this article