Connect with us


Could gene therapy be the answer?

Could gene therapy be the answer?


Obesity and related metabolic disorders such as type 2 diabetes are major public health concerns.

Nearly one in four people are obese, according to the Organization for Economic Co-operation and Development (OECD). Over the next 30 years, obesity and overweight-related diseases are expected to shorten her life expectancy by nearly three years.

But traditional methods for reversing obesity are ineffective in the long run, researchers say. Diet and lifestyle approaches are important, but other methods are often needed.

“Current obesity treatments include pharmacological and bariatric surgical approaches, both of which have limitations in long-term efficacy.” Laura Herrero, associate professor at the Institute of Biomedical Sciences at the University of Barcelona, ​​told FoodNavigator.

Working with the scientific team at the University of Barcelona and the public research consortium CIBERobn, Herrero designed another strategy to combat obesity and diabetes and tested it in mice.

In vitro gene therapy for obesity reduction

“Gene therapy approaches have the potential to target diseases caused by genetic mutations.” Herrero explained. “In preclinical studies in laboratory mice, we used a gene therapy approach to express proteins involved in fat oxidation, enhancing the cells’ ability to burn fat.”

this is, ex vivo A gene therapy technique that generates and transplants cells that express the CPT1AM protein. The CPT1AM protein is an enzyme that resides in mitochondria and plays a critical role in many metabolic diseases, including obesity.

“Modified stem cells isolated from adipose tissue with enhanced lipid oxidation were transplanted into obese mice, resulting in weight loss and lower serum glucose, insulin and cholesterol levels.” we were told

The researchers concluded that transplantation of adipocytes expressing the mitochondrial enzyme CPT1AM helped reduce obesity and glucose intolerance in mice, and the results support future clinical use. ex vivo Gene therapy approaches as a new strategy for reducing obesity and cholesterol rates in the population.

“If there is a potential future application of this approach from mice to humans, we will consider and optimize several aspects, including isolation steps, implant survival and functionality in long-term studies, and maintenance of obesity improvement.” You need a phenotype Herrero told the publication.

How’s your diet and exercise?

Of course, such treatments do not take away the importance of lifestyle measures.

“Evolving a healthy lifestyle will not only help with obesity, but many other metabolic diseases as well.” we were told “Thus, lifestyle interventions are always recommended.”

Policy makers are increasingly intervening to encourage lifestyle changes where necessary and to help translate such changes into environmental benefits. According to the European Commission’s farm-to-fork strategy, the European diet as a whole is not in line with national dietary recommendations, and the ‘food environment’ has always made healthy choices the easiest. There is no guarantee.

“If European diets were to follow dietary recommendations, the environmental impact of the food system would be significantly reduced.”

The Commission advocates a shift to a more plant-based diet, with less red and processed meat and more fruits and vegetables, to help consumers make informed decisions through farm-to-fork strategies. We want to make healthy and sustainable food choices possible.

Related policies include mandatory front-of-pack nutrition labeling and proposed tax incentives to encourage consumers to make sustainable and healthy dietary choices.

sauce: metabolic engineering
“Transplantation of Adipocytes Expressing CPT1AM Reduces Obesity and Glucose Intolerance in Mice”
Published online on April 22, 2023
Authors: MC Soler Vazquez, M Romero, L Herrero and others.




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]