Health
Findings suggest older siblings may help build a baby’s defenses against allergies
Erin Tucker never leaves home without multiple Epipens, Ventolin and other life-saving medications for her son Flynn.
Key Point:
- Babies with older siblings form a more mature worm community in the gut by the age of one year.
- Reduced risk of food allergies in the same babies
- Scientists are now testing whether bacteria can be used as an oral treatment to build a healthy response to viral infections.
The 5-year-old was diagnosed with milk and egg allergies at 2 months of age, and later developed nut, sesame and latex allergies and asthma.
He had 12 anaphylactic reactions.
“Nothing we do is spontaneous and requires a lot of planning,” Tucker said.
“If you want to go out for the weekend or take a day trip, we are always doing a risk assessment of how close the location is to an ambulance or a hospital for quick intubation.
“We have to take all his food with us wherever we go.”
Mr. Tucker said that such logistics planning became easier over time.
“But the hardest part is calling an ambulance and praying to God,” she says.
Flynn’s sister, Zoe, has also been diagnosed with an allergy, but Tucker said it wasn’t as widespread or severe as it is.
Mr. and Mrs. Tucker think it may be because of Flynn.
The missing piece of the food allergy puzzle
Researchers have known for more than 30 years that children from large families are less likely to develop allergic diseases, but the potential reasons for this have remained a mystery.
Researchers from Barwon Health, Deakin University, and Murdoch Children’s Research Institute used long-term data from the Barwon Infant Study to show how older siblings can speed up development of babies’ gut microbiota and protect against allergic disease. demonstrated that
The Barwon Infant Study has been running since 2010 and collects information from over 1,000 mother-infant pairs in the Geelong area recruited from birth to study childhood developmental milestones.
The researchers used poop samples to measure the infant’s gut bacteria and tested for allergies to five different foods at one year of age.
The survey results are Published in Journal of Allergy and Clinical Immunologyparticipants with older siblings were shown to have more mature gut microbiota by the age of 1 year.
“We still don’t know exactly why that’s happening, but what’s probably happening is that we’re all constantly infecting each other with bacteria,” said study leader Peter Vuillermin, a Barwon Health pediatrician. It means that we share the
“What we found very clearly was that the more siblings children had at one year of age, the lower the risk of food allergies,” said Professor Vilarmin.
Emad El Omar, director of the Microbiome Research Center in New South Wales, said newborns experience a “transitional microbiome” as they come into contact with more sources of bacteria.
“It’s kind of a precarious period because the baby continues to be exposed to the environment, other members of the family, pets and many other different things,” said Professor El Omar.
“Obviously, more members living together will increase the diversity of the microbiome even more.”
Professor El Omar said Australians are increasingly aware of the impact of microbiome and gut health on overall mental and physical health.
“From my experience with people here, I’m really, really excited about the fact that there’s a growing awareness of gut health in general. We all know gut health is involved. he said.
“Thanks to the excellent research underway in Australia, we are always aware of what is happening around the world and we will benefit greatly over the next five years.”
Scientists hope to develop their findings further in trials
Researchers are currently recruiting more than 2,000 children across Australia and New Zealand for clinical trials based on findings from the Barwon Infant Study data.
The trial will test whether a mixture of orally ingested killed bacteria can protect young children from asthma and other wheezing disorders by promoting healthy responses to viral infections.
Flynn Tucker takes a probiotic pill to see if it boosts her gut microbiome and protects her from allergens.
Approximately 1 in 10 Australian babies will develop a food allergy.
Tucker said her family felt honored to be part of the clinical trial.
“We are known as the allergy capital of the world,” Tucker said.
“That means we may find a cure for asthma and food allergies, which will have a huge impact on Mr. Flynn’s life and our quality of life,” she said.
“And that could mean that there will be families in the future who don’t experience allergies or travel like we did.”
Professor El Omar believes patients may eventually be able to tailor probiotic treatments to their specific allergies and problems.
“What’s going to happen in the next five years or so is that I think we’ll learn a lot more about individualizing interventions,” he said.
“I think that with more and more knowledge, and certainly a more focused kind of therapy, we might be able to manipulate it with the appropriate microbiome consortium that is missing.
“That’s something we can break through. Through the right clinical trials and the right selection of these probiotics, I think we can definitely make progress.”
Professor Buillermin said the prevalence of food allergies in Australian society is increasing.
“We know that the incidence of food-allergic anaphylaxis, the most severe form of food allergy, has tripled since the 1990s.
“Australia has long had one of the highest rates of asthma in the world and asthma is a very important public health problem and we desperately need prevention strategies.”
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