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Biological aging increases risk of depression and anxiety in adults

Biological aging increases risk of depression and anxiety in adults


Yinan Zheng, Ph.D., assistant professor of preventive medicine in the Division of Cancer Epidemiology and Prevention, is a co-author of the study published in Nature Communications.

Advanced biological aging may increase the risk of depression and anxiety in middle-aged adults, according to recent research published of Nature Communications.

Depression and anxiety are two of the most common mental health disorders among adults in the United States, but the link between mental health and aging is not fully understood. It is further unknown whether accelerating the biological aging process increases the risk of these mental health disorders in older adults.

“This is important because mental health problems in older adults are often comorbid and therefore often overlooked or untreated. It can have serious health consequences,” he said. Dr. Yi Nam ChungAssistant Professor preventive medicine in the department of Cancer epidemiology and prevention He is also a co-author of the study.

In this study, researchers identified a link between biological age and rates of depression and anxiety in more than 420,000 adult participants in the UK Biobank database. .

The biological age of participants was measured using two validated algorithms, the KDM-BA algorithm and the PhenoAge algorithm, implemented using biobank data. Both algorithms use specific biomarkers to calculate a person’s predicted biological age.

“To quantify inter-participant differences in biological aging, we regressed the calculated biological age values ​​by chronological age at the time of biomarker measurement and calculated residual values. These residual values. is called the ‘accelerated aging (AA)’ value for measuring biological aging,” said Zheng, who is also a member of the study group. Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

At baseline, biologically older participants were more likely to experience depression and anxiety, and over eight years of follow-up, participants with older biological age, regardless of genetic risk or medical history, There was an increased risk of depression and anxiety.

“This finding supports the hypothesis that biological aging may be a risk factor for depression and anxiety in middle-aged and older adults,” said Dr. It suggests future directions for potential therapeutics targeting science,” Zheng said.

The researchers also found that certain biomarkers included in the algorithm (such as creatinine and albumin) are associated with mental health outcomes, and that biological aging is associated with inflammation, oxidative stress, and metabolic dysregulation in healthy cells. I also found that there is a possibility that

“This finding may also provide insight into the biological mechanisms underlying the link between aging and mental health,” Zheng said.

According to Zheng, the current findings explore the link between biological aging and certain mental health disorders, identify additional biological mechanisms underlying it, and suggest that certain interventions may reduce biological aging. It supports the need for additional research to determine whether delay can improve mental health outcomes.

This work was supported by grants from the National Natural Science Foundation of China, the China CDC Center for Environmental Population Health, Peking University, and the Canadian Institute for Advanced Study CBD Network.




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