Coronavirus: Obesity and Metabolic Syndrome are Risk Factors for Severe Influenza Covid-19-Health

Metabolic syndrome Virus infection, According to a review of the literature conducted by a team of researchers at the School of Biomedical Sciences in St. Jude and the University of Tennessee Health Science Center in both Memphis.

This work was published in the Journal of Virology, a publication of the American Society for Microbiology.

Metabolic syndrome is a cluster of at least three coexisting conditions that increase the risk of heart disease, stroke, and type 2 diabetes (T2DM). These conditions include excessive abdominal fat, hypertension, excessive blood sugar, lipid abnormalities (including excess triglycerides and cholesterol), insulin resistance, and inflammatory conditions.

Studies have shown that obesity is associated with increased severity of influenza A, increased viral titers in exhaled breath, and long-term viral infection.

Reported changes in the viral population may prevent the emergence of more pathogenic influenza variants. Despite the fact that the influenza vaccine produces strong antibody titers in obese subjects, obesity doubles the chance of developing influenza.

Like the influenza virus, the Centers for Disease Control and Prevention recently recognized obesity as a risk factor for severe illness caused by SARS-CoV-2.

“This is not surprising, because excess weight and buildup of fat put pressure on the diaphragm, making breathing more difficult during viral infections,” the researchers write.

But the risk goes beyond the burden of excess weight. A recent study highlighted in the literature review examined 174 diabetic patients with confirmed cases of COVID-19. The study found that these patients were at significantly higher risk of severe pneumonia compared to non-diabetic COVID-19 patients. CT scans revealed the severity of lung abnormalities in these patients.

The researchers also note that there is also a significant increase in serum IL-6 levels, which is a predictive biomarker of disease severity. These data suggest that SARS-CoV-2 causes severe disease in obese and T2DM patients by inducing bilateral pneumonia and a cytokine storm that damages the lung epithelial endothelial barrier.

However, one hypothetical risk of T2DM patients with hypertension or heart disease reportedly does not seem to matter after all. These patients are commonly treated with angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). These increase the expression of ACE2, the receptor SARS-CoV-2 uses to gain entry into the cell.

Clinicians and researchers initially feared that ACE inhibitors and ARBs could promote adhesion and entry of SARS-CoV-2 into host cells, thereby increasing the risk of severe COVID-19. It was Contrary to concern, studies suggest that ACE inhibitors and ARB do not lead to poor outcomes of COVID-19 infection.

“Future research [determine] The researchers investigated how metabolic abnormalities increase the pathogenesis of the virus, as this information plays an essential role in global preparedness for emerging seasonal and pandemic virus strains.

ASM keeps track of the SARS-CoV-2 pandemic using the COVID-19 Research Registry, a top-ranked research article curated by experts. From a pandemic perspective, this curated database will enable scientists, journalists, and the general public to streamline the most timely and most valuable SARS-CoV-2/COVID-19 research from the latest journal articles and preprints. Make sure you find the right way.

The American Society for Microbiology is one of the largest professional societies specializing in life sciences, consisting of 30,000 scientists and health professionals. ASM’s mission is to promote and advance microbial science.

ASM promotes microbial science through conferences, publications, certifications and educational opportunities. Empower labs around the world with training and resources. It provides a network for academia, industry, and clinical scientists. In addition, ASM promotes a deeper understanding of microbial science to a diverse audience.

(This article has been published from the telegraph agency feed with no changes to the text. Only the headings have changed.)

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