COVID-19 Update: Multiple Scientists Claim Mutations Increase Risk of Coronavirus

The virus mutates, so the influenza vaccine needs to be upgraded each year. However, there are many unclear points about coronaviruses, so it becomes more anxious to know that the virus is mutated.

Scientists found that SARS-CoV-2 mutants were more contagious in July after 78% of patients worldwide were found to have SARS-CoV-2 mutants, which surged sharply from 10% in March. Revealed the discovery that.

Columbia University virologist Vincent Racaniello said there is no evidence that the mutated SARS-CoV-2 strain increased human infection after cell studies. Could not provide Proof. Racaniello added that the work was based on lab experiments with pseudoviruses rather than actual SARS-CoV-2. To prove that a mutation is highly contagious, we need to study how the actual mutant strain behaves in the human body.

(Photo: REUTERS / Vladimir Pirogov)
On July 16, 2020, at a school gym in Bishkek, Kyrgyzstan, a free day-trip hospital, a health care professional with personal protective equipment (PPE) treats a patient. The Opening of Healthcare Facility for Coronavirus Disease (COVID-19) Outbreak was initiated by a local businessman who is currently funding the drug, equipment and salary payments.

Meanwhile, Yale University epidemiologist and virologist Nathan Grubaugh pointed out that there is a huge gap between laboratory and human infections. The virus, according to Dr. Grubow, must allow mucus and immune cells to cross the airways to the lungs. It mimics itself and returns to the air via droplets. The findings of the Cell study are reasonable, but there are many other variables.

First, researchers did not use the actual SARS-CoV-2 virus because the Cell study performed the experiment in the lab using a pseudovirus. To show that mutations make them more contagious, we need to observe how real mutants behave in people.

The COVID-19 Genomics UK Consortium tracks G614 mutations in British patients, Analyze over 30,000 genomes.. The British consortium also found no evidence that G614 made coronavirus infections more severe or more lethal. According to Eric Vaults, an epidemiologist at Imperial College London, the G614 mutation may increase infection rates among humans, but there are no differences in test results.

G614 mutation: what we know so far

Cellular researchers, led by Bette Korber, a biologist at Los Alamos National Laboratory in New Mexico, cut and paste coronavirus spike proteins into lentivirus embryos.

(Photo: REUTERS / Dado Ruvic / Illustration)
The 3D-printed coronavirus model appears before the word coronavirus disease (COVID-19) shown in this figure, taken on March 25, 2020.

Research results suggest that mutations involving a single change in the “spike” protein can somehow improve the ability of the virus to enter and replicate in human cells. Korber explains that “fake viruses” are a safe way to handle and compare virus spikes.

Scientists have mixed these pseudoviruses with different types of kidney cells in vitro. These include cells extracted from velvet monkeys 60 years ago and cells taken from humans in 1973. In this lab scenario, the mutated spike was found to be more infectious.

This was briefly covered by the media earlier this month, leading to many amazing articles. The fact that the G614 mutation surged in months made the virus seem more contagious.

Despite the seemingly worrisome findings, Ravaniello said there is still no information about how they can affect humans while Cover is aware of the limitations of the findings. It was

The G614 mutation was first discovered in January in China, as the new coronavirus spreads throughout the world.

Also read: COVID-19 Vaccine: All Participants in the Moderna Vaccine Trial Produce Antibodies

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