Health
New drug to fight Alzheimer’s disease
Donanemab is currently making headlines as a drug that appears to slow the decline of memory and thinking skills in people with early-stage Alzheimer’s disease. Donanemab is a disease-modifying therapy. This means that we can not only alleviate the symptoms, but also approach the root cause. In addition to donanemab, another Alzheimer’s drug called lecanemab was approved by the FDA in January 2023. These two treatments, he said, act similarly and have similar efficacy and side effect profiles, so it is helpful to discuss them as a group rather than individually.
Donanemab is a revolutionary treatment in the fight against Alzheimer’s disease, according to Dr. Meredith Wickland, senior associate consultant at the Mayo Clinic in Arizona.
“This drug was studied in people with what we call ‘mild cognitive impairment.’ but mild enough that it means that even if you notice it every day, there is no functional impairment.” They are quite capable of doing it themselves,” said Dr. Wickland.
People who tested donanemab in the study were treated for 12 to 18 months, and the treatment targeted amyloid protein, a protein associated with Alzheimer’s disease. One of the main side effects observed with this treatment is swelling of the brain. Dr. Wickland said swelling in the brain can cause serious symptoms, but it doesn’t happen in all patients.
Donanemab is currently administered as a monthly IV treatment. Dr. Wickland recommends that older adults who believe they are experiencing cognitive decline see a neurologist to be tested for dramatic cognitive decline.
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