Health
Researchers automate the development of polymers that fight bacteria
In a study published this week in a journal Advanced science, Researchers have detailed polymers that they claim to be effective against antibiotic resistant bacteria. In this project, IBM researchers teamed up with scientists from the Science and Technology Agency and the Research and Technology Alliance of Singapore MIT. Researchers say their technology has enabled them to produce polymers that fight up to 100 bacteria in 9 minutes. They believe that these polymers can be combined with other therapeutic agents to make them more effective.
Antibiotics have changed the medical world in the last century or so, but they have been misused and led to the emergence of strongly resistant bacteria. “Gram-negative” pathogens that cause E. coli, Salmonella, pneumonia, tuberculosis, and sepsis are particularly problematic because the outer membrane can protect them from antibiotics such as penicillin. among Rapid increase in drug-resistant infectionsThe World Health Organization (WHO) has identified Gram-negative bacteria as an “important priority.”
Combination therapy is receiving attention as a method of treating multidrug-resistant (MDR) bacteria, where a biodegradable polymer called broad-spectrum antibacterial guanidinium-functionalized polycarbonate, combined with antituberculosis and antirheumatic drugs, has shown results. It shows that it can be “moderately” improved. Inspired by this, IBM researchers and their colleagues designed a process for testing and exploring different polymers to increase the potency of antibiotics and repeated until the most effective polymer was identified.
Antibiotic resistance, usually caused by “sublethal” drug administration, occurs when bacteria modify enzymes, proteins, or genes. Researchers’ polymers appear to prevent this by attaching to modifying enzymes, allowing drugs to bypass protective measures and be effective. It also suggests that the required dose can be reduced to levels below that used by weaker strains, and drugs can be strengthened to combat more serious (and potentially deadly) infections.
For example, in an MDR experiment a. Baumannii, The co-authors state that the presence of the copolymer improved the effects of the drugs azithromycin, gentamicin, imipenem, tetracycline, and colistin when they could cause infections in the blood, urinary tract, and lungs. In another experiment, this polymer allowed the team to reuse and fight the anti-tuberculosis and anti-rheumatic drugs rifampicin and auranofin, which are usually ineffective against Gram-negative bacteria. a. Baumanni “Strong”. In particular, rifampicin therapy appeared to promote bacterial death by stressing the intracellular fluid, the cytosol.
“In the future, we will leverage the knowledge gained in this work, previous work in automated programmatic polymer synthesis, and IBM’s AI capabilities to rapidly develop new polymer adjuvants. The therapeutic coverage can range from treatment of drug-resistant pathogens and cancer to new antiviral therapies,” the researchers wrote in a blog post. “The global crisis of antibiotic resistance continues to grow at a phenomenal pace. In the absence of a new class of potent antibiotic drugs that could help curb the effects of this resistance, our study announced. Applying such a combination approach of therapies could have great potential to combat MDR Gram-negative infections.”
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