Health
Researchers demonstrate production of viral parts within artificial cells
Every scientist looking for a better diagnostic test, drug, or vaccine for a virus must start by deciphering the structure of the virus. And if the viruses in question are highly pathogenic, it is very dangerous to investigate, test, or develop them. Professor Leubarjif, Staff Scientist Dr. Shirley Surmandoub, Dr. Ohad von Shack, former researcher of the Barjif lab and now researcher Iftach Divon has a unique solution to this obstacle. They showed the production of viral parts in artificial cells.
The cell is a micrometer-sized compartment etched into a silicon chip. At the bottom of each compartment, scientists stuck DNA strands and packed them tightly together. The ends of the artificial cells were covered with receptors that could trap the proteins produced inside the cells. First, scientists killed a cell with everything it needed to make a protein-the molecules and enzymes needed to read DNA information and translate it into a protein. Then, without human intervention, the receptor carpet traps one of the proteins produced at the bottom of the cell, and the remaining viral proteins bind to each other, creating a structure that scientists previously “programmed” into the system. Did. In this case, they created various small parts of the virus (bacteriophage) that infect bacteria.
We have discovered that engineered cells can control both efficiency and end product assembly processes. This includes cell geometry and gene arrangement and organization. They all determine which proteins are produced and, in the future, what these proteins are produced when they are assembled. “
Roy Burjiv, Professor
“Because these are small artificial cells, we can have so many cells on one chip. We can change the design of different cells to perform different tasks at different locations on the same chip.” .”
The features of the system developed at the Wiseman Institute-including the ability to produce different small parts of a single virus at once-are used by scientists around the world to evaluate tests, drugs, and vaccines against that virus. Can give you new tools. Add Divon. “The artificial part-even if it replicates part of the virus-is particularly safe from start to finish, as it does not involve the use of the actual virus.” “Another possible application,” Shulman Daube says “It could be the development of a chip that can perform thousands of medical tests at once quickly and efficiently,” he said.
Participants in this study were Dr. Stephanie Ferste, Dr. Sofia Rudolf and Professor Reinhard Lipowski of the Max Planck Colloid and Interface Research Institute in Potsdam, Germany, and Professor Vincent Neuloh of the University of Minnesota. The study was published in the book today Natural nanotechnology..
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