Health
A comprehensive dataset of animal-associated sarbecoviruses
Lytras, S., Xia, W., Hughes, J., Jiang, X. W. & Robertson, D. L. The animal origin of SARS-CoV-2. Science 373, 968–970 (2021).
Ye, Z. W. et al. Zoonotic origins of human coronaviruses. Int J Biol Sci 16, 1686–1697 (2020).
Boni, M. F. et al. Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic. Nat Microbiol 5, 1408–1417 (2020).
Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C. & Garry, R. F. The proximal origin of SARS-CoV-2. Nat Med 26, 450–452 (2020).
Pramod, R. K. et al. Reverse zoonosis of coronavirus disease-19: Present status and the control by one health approach. Vet World 14, 2817–2826 (2021).
Latif, A. A. & Mukaratirwa, S. Zoonotic origins and animal hosts of coronaviruses causing human disease pandemics: A review. Onderstepoort J Vet 87, e1–e9 (2020).
Jones, K. E. et al. Global trends in emerging infectious diseases. Nature 451, 990–993 (2008).
Sayers, E. W. et al. GenBank 2023 update. Nucleic Acids Res 51, D141–D144 (2022).
Zhou, S. Y. et al. ZOVER: the database of zoonotic and vector-borne viruses. Nucleic Acids Res 50, D943–D949 (2022).
Schoch, C. L. et al. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database 2020, baaa062 (2020).
Wan, Y. S., Shang, J., Graham, R., Baric, R. S. & Li, F. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol 94, e00127–00120 (2020).
Li, P. et al. Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses. Plos Pathog 19, e1011116 (2023).
Liu, B. et al. A comprehensive dataset of animal-associated sarbecoviruses. figshare https://doi.org/10.6084/m9.figshare.22678132 (2023).
Aguiló-Gisbert, J. et al. First description of SARS-CoV-2 infection in two feral American mink (Neovison vison) caught in the wild. Animals 11, 1422 (2021).
Alberto-Orlando, S. et al. SARS-CoV-2 transmission from infected owner to household dogs and cats is associated with food sharing. Int J Infect Dis 122, 295–299 (2022).
Alkhovsky, S. et al. SARS-like coronaviruses in horseshoe bats (Rhinolophus spp.) in Russia, 2020. Viruses 14, 113 (2022).
Anthony, S. J. et al. Global patterns in coronavirus diversity. Virus Evol 3, vex012 (2017).
Ar Gouilh, M. et al. SARS-CoV related Betacoronavirus and diverse Alphacoronavirus members found in western old-world. Virology 517, 88–97 (2018).
Barroso-Arevalo, S. et al. Large-scale study on virological and serological prevalence of SARS-CoV-2 in cats and dogs in Spain. Transbound Emerg Dis 69, e759–e774 (2022).
Barroso-Arévalo, S., Rivera, B., Domínguez, L. & Sánchez-Vizcaíno, J. M. First detection of SARS-CoV-2 B. 1.1. 7 variant of concern in an asymptomatic dog in Spain. Viruses 13, 1379 (2021).
Barroso-Arevalo, S., Sanchez-Morales, L., Perez-Sancho, M., Dominguez, L. & Sanchez-Vizcaino, J. M. First Detection of SARS-CoV-2 B.1.617.2 (Delta) Variant of Concern in a Symptomatic Cat in Spain. Front Vet Sci 9, 841430 (2022).
Barrs, V. R. et al. SARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, China. Emerg Infect Dis 26, 3071–3074 (2020).
Bui, V. N. et al. SARS-CoV-2 Infection in a Hippopotamus, Hanoi, Vietnam. Emerg Infect Dis 29, 658–661 (2023).
Carvalho, P. P. D. & Alves, N. A. Featuring ACE2 binding SARS-CoV and SARS-CoV-2 through a conserved evolutionary pattern of amino acid residues. J Biomol Struct Dyn 40, 11719–11728 (2022).
Carvallo, F. R. et al. Severe SARS-CoV-2 infection in a cat with hypertrophic cardiomyopathy. Viruses 13, 1510 (2021).
Caserta, L. C. et al. White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern. Proc Natl Acad Sci USA 120, e2215067120 (2023).
Chen, W. et al. SARS-associated coronavirus transmitted from human to pig. Emerg Infect Dis 11, 446–448 (2005).
Chidoti, V. et al. Longitudinal survey of coronavirus circulation and diversity in insectivorous bat colonies in Zimbabwe. Viruses 14, 781 (2022).
Crook, J. M. et al. Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe. Sci Rep 11, 14723 (2021).
Decaro, N. et al. Possible Human-to-Dog Transmission of SARS-CoV-2, Italy, 2020. Emerg Infect Dis 27, 1981–1984 (2021).
Drexler, J. F. et al. Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences. J Virol 84, 11336–11349 (2010).
Ferasin, L. et al. Infection with SARS-CoV-2 variant B.1.1.7 detected in a group of dogs and cats with suspected myocarditis. Vet Rec 189, e944 (2021).
Garigliany, M. et al. SARS-CoV-2 Natural Transmission from Human to Cat, Belgium, March 2020. Emerg Infect Dis 26, 3069–3071 (2020).
Ge, X. Y. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 503, 535–538 (2013).
Gortazar, C. et al. Natural SARS-CoV-2 Infection in Kept Ferrets, Spain. Emerg Infect Dis 27, 1994–1996 (2021).
Guan, Y. et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science 302, 276–278 (2003).
Guo, H. et al. Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor. Emerg Microbes Infect 10, 1507–1514 (2021).
Hale, V. L. et al. SARS-CoV-2 infection in free-ranging white-tailed deer. Nature 602, 481–486 (2022).
Hamdy, M. E. et al. Mutations of the SARS-CoV-2 Spike Glycoprotein Detected in Cats and Their Effect on Its Structure and Function. Front Cell Infect Microbiol 12, 875123 (2022).
Hamdy, M. E. et al. SARS-CoV-2 infection of companion animals in Egypt and its risk of spillover. Vet Med Sci 9, 13–24 (2023).
Hamer, S. A. et al. SARS-CoV-2 infections and viral isolations among serially tested cats and dogs in households with infected owners in Texas, USA. Viruses 13, 938 (2021).
Hammer, A. S. et al. SARS-CoV-2 Transmission between Mink (Neovison vison) and Humans, Denmark. Emerg Infect Dis 27, 547–551 (2021).
Han, Y. et al. Identification of Diverse Bat Alphacoronaviruses and Betacoronaviruses in China Provides New Insights Into the Evolution and Origin of Coronavirus-Related Diseases. Front Microbiol 10, 1900 (2019).
He, B. et al. Identification of diverse alphacoronaviruses and genomic characterization of a novel severe acute respiratory syndrome-like coronavirus from bats in China. J Virol 88, 7070–7082 (2014).
Hu, B. et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. Plos Pathog 13, e1006698 (2017).
Hu, D. et al. Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats. Emerg Microbes Infect 7, 154 (2018).
Ip, H. S. et al. An opportunistic survey reveals an unexpected coronavirus diversity hotspot in North America. Viruses 13, 2016 (2021).
Jairak, W. et al. SARS-CoV-2 delta variant infection in domestic dogs and cats, Thailand. Sci Rep 12, 8403 (2022).
Jairak, W. et al. First cases of SARS-CoV-2 infection in dogs and cats in Thailand. Transbound Emerg Dis 69, e979–e991 (2022).
Janies, D., Habib, F., Alexandrov, B., Hill, A. & Pol, D. Evolution of genomes, host shifts and the geographic spread of SARS-CoV and related coronaviruses. Cladistics 24, 111–130 (2008).
Kan, B. et al. Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol 79, 11892–11900 (2005).
Karikalan, M. et al. Natural infection of Delta mutant of SARS-CoV-2 in Asiatic lions of India. Transbound Emerg Dis 69, 3047–3055 (2022).
Keller, M. et al. Detection of SARS-CoV-2 variant B.1.1.7 in a cat in Germany. Res Vet Sci 140, 229–232 (2021).
Kim, Y. et al. Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea. Virus Genes 55, 545–549 (2019).
Kok, K. H. et al. Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerg Microbes Infect 11, 689–698 (2022).
Kuhlmeier, E. et al. Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland. Viruses 15, 245 (2023).
Kumar, D. et al. Surveillance and Molecular Characterization of SARS-CoV-2 Infection in Non-Human Hosts in Gujarat, India. International Journal of Environmental Research and Public Health 19, 14391 (2022).
Lam, T. T. et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature 583, 282–285 (2020).
Latinne, A. et al. Origin and cross-species transmission of bat coronaviruses in China. Nat Commun 11, 4235 (2020).
Lau, S. K. et al. Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. J Virol 89, 10532–10547 (2015).
Lau, S. K. et al. Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events. J Virol 84, 2808–2819 (2010).
Lau, S. K. et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA 102, 14040–14045 (2005).
Lelli, D. et al. Detection of coronaviruses in bats of various species in Italy. Viruses 5, 2679–2689 (2013).
Li, L. et al. Epidemiological Study of Betacoronaviruses in Captive Malayan Pangolins. Front Microbiol 12, 657439 (2021).
Li, L. et al. Epidemiology and Genomic Characterization of Two Novel SARS-Related Coronaviruses in Horseshoe Bats from Guangdong, China. mBio 13, e0046322 (2022).
Li, L. L. et al. A novel SARS-CoV-2 related coronavirus with complex recombination isolated from bats in Yunnan province, China. Emerg Microbes Infect 10, 1683–1690 (2021).
Li, W. et al. Bats are natural reservoirs of SARS-like coronaviruses. Science 310, 676–679 (2005).
Lin, X. D. et al. Extensive diversity of coronaviruses in bats from China. Virology 507, 1–10 (2017).
Liu, P. et al. Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)? Plos Pathog 16, e1008421 (2020).
Liu, P. et al. Correction: Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)? Plos Pathog 17, e1009664 (2021).
Mahajan, S. et al. Detection of SARS-CoV-2 in a free ranging leopard (Panthera pardus fusca) in India. Eur J Wildl Res 68, 59 (2022).
Marques, A. D. et al. Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania. mBio 13, e0210122 (2022).
McAloose, D. et al. From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo. MBio 11, https://doi.org/10.1128/mbio.02220-02220 (2020).
Mishra, A. et al. SARS-CoV-2 Delta Variant among Asiatic Lions, India. Emerg Infect Dis 27, 2723–2725 (2021).
Mitchell, P. K. et al. SARS-CoV-2 B.1.1.7 Variant Infection in Malayan Tigers, Virginia, USA. Emerg Infect Dis 27, 3171–3173 (2021).
Mohebali, M. et al. SARS-CoV-2 in domestic cats (Felis catus) in the northwest of Iran: Evidence for SARS-CoV-2 circulating between human and cats. Virus Res 310, 198673 (2022).
Molini, U. et al. SARS-CoV-2 in Namibian dogs. Vaccines 10, 2134 (2022).
Moraga-Fernandez, A. et al. A study of viral pathogens in bat species in the Iberian Peninsula: identification of new coronavirus genetic variants. Int J Vet Sci Med 10, 100–110 (2022).
Moreno, A. et al. SARS-CoV-2 in a mink farm in Italy: case description, molecular and serological diagnosis by comparing different tests. Viruses 14, 1738 (2022).
Murakami, S. et al. Isolation of Bat Sarbecoviruses, Japan. Emerg Infect Dis 28, 2500–2503 (2022).
Murakami, S. et al. Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan. Emerg Infect Dis 26, 3025–3029 (2020).
Nagy, A. et al. Reverse-zoonotic transmission of SARS-CoV-2 lineage alpha (B.1.1.7) to great apes and exotic felids in a zoo in the Czech Republic. Arch Virol 167, 1681–1685 (2022).
Neira, V. et al. A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners. Emerg Microbes Infect 10, 376–383 (2021).
Nga, N. T. T. et al. Evidence of SARS-CoV-2 Related Coronaviruses Circulating in Sunda pangolins (Manis javanica) Confiscated From the Illegal Wildlife Trade in Viet Nam. Front Public Health 10, 826116 (2022).
Oreshkova, N. et al. SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020. Eurosurveillance 25, 2001005 (2020).
Orłowska, A. et al. The genetic characterization of the first detected bat coronaviruses in Poland revealed SARS-related types and alphacoronaviruses. Viruses 14, 1914 (2022).
Padilla-Blanco, M. et al. The Finding of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in a Wild Eurasian River Otter (Lutra lutra) Highlights the Need for Viral Surveillance in Wild Mustelids. Front Vet Sci 9, 826991 (2022).
Padilla-Blanco, M. et al. Detection of SARS-CoV-2 in a dog with hemorrhagic diarrhea. Bmc Vet Res 18, 370 (2022).
Panzera, Y. et al. Detection and genome characterisation of SARS-CoV-2 P.6 lineage in dogs and cats living with Uruguayan COVID-19 patients. Mem Inst Oswaldo Cruz 117, e220177 (2023).
Pauly, M. et al. Novel alphacoronaviruses and paramyxoviruses cocirculate with type 1 and severe acute respiratory system (SARS)-related betacoronaviruses in synanthropic bats of Luxembourg. Applied and environmental microbiology 83, e01326–01317 (2017).
Peng, M. S. et al. The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks. Zool Res 42, 834–844 (2021).
Piewbang, C. et al. SARS-CoV-2 Transmission from Human to Pet and Suspected Transmission from Pet to Human, Thailand. J Clin Microbiol 60, e0105822 (2022).
Rihtaric, D., Hostnik, P., Steyer, A., Grom, J. & Toplak, I. Identification of SARS-like coronaviruses in horseshoe bats (Rhinolophus hipposideros) in Slovenia. Arch Virol 155, 507–514 (2010).
Sander, A. L. et al. Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses. Commun Biol 5, 491 (2022).
Schiaffino, F. et al. First Detection and Genome Sequencing of SARS-CoV-2 Lambda (C.37) Variant in Symptomatic Domestic Cats in Lima, Peru. Front Vet Sci 8, 737350 (2021).
Sirakov, I. et al. Development of Nested PCR for SARS-CoV-2 Detection and Its Application for Diagnosis of Active Infection in Cats. Veterinary Sciences 9, 272 (2022).
Sit, T. H. C. et al. Infection of dogs with SARS-CoV-2. Nature 586, 776–778 (2020).
Song, H. D. et al. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci USA 102, 2430–2435 (2005).
Suzuki, J., Sato, R., Kobayashi, T., Aoi, T. & Harasawa, R. Group B betacoronavirus in rhinolophid bats, Japan. J Vet Med Sci 76, 1267–1269 (2014).
Tang, X. C. et al. Prevalence and genetic diversity of coronaviruses in bats from China. J Virol 80, 7481–7490 (2006).
Tao, Y. & Tong, S. Complete genome sequence of a severe acute respiratory syndrome-related coronavirus from Kenyan bats. Microbiology resource announcements 8, e00548–19 (2019).
Temmam, S. et al. Bat coronaviruses related to SARS-CoV-2 and infectious for human cells. Nature 604, 330–336 (2022).
Urushadze, L. et al. A cross sectional sampling reveals novel coronaviruses in bat populations of Georgia. Viruses 14, 72 (2021).
Wacharapluesadee, S. et al. Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia. Nat Commun 12, 972 (2021).
Wang, J. et al. Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential. Nature Communications 14, 4079 (2023).
Wang, L. et al. Discovery and genetic analysis of novel coronaviruses in least horseshoe bats in southwestern China. Emerg Microbes Infect 6, e14 (2017).
Wang, L. et al. Complete genome sequence of SARS-CoV-2 in a tiger from a US zoological collection. Microbiology resource announcements 9, e00468–20 (2020).
Wang, M. et al. SARS-CoV infection in a restaurant from palm civet. Emerg Infect Dis 11, 1860–1865 (2005).
Wang, W. et al. Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence. Virus Evol 8, veac046 (2022).
Wang, N. et al. Characterization of a new member of alphacoronavirus with unique genomic features in Rhinolophus bats. Viruses 11, 379 (2019).
Wells, H. L. et al. The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus. Virus Evol 7, veab007 (2021).
Wu, Z. et al. Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases. ISME J 10, 609–620 (2016).
Wu, Z. et al. ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. J Infect Dis 213, 579–583 (2016).
Wu, Z. et al. A comprehensive survey of bat sarbecoviruses across China in relation to the origins of SARS-CoV and SARS-CoV-2. Natl Sci Rev 10, nwac213 (2023).
Xiao, K. et al. Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature 583, 286–289 (2020).
Xu, L. et al. Detection and characterization of diverse alpha- and betacoronaviruses from bats in China. Virol Sin 31, 69–77 (2016).
Yang, L. et al. Novel SARS-like betacoronaviruses in bats, China, 2011. Emerg Infect Dis 19, 989–991 (2013).
Yang, X. L. et al. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. J Virol 90, 3253–3256 (2015).
Yuan, J. et al. Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans. J Gen Virol 91, 1058–1062 (2010).
Zhou, H. et al. A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein. Curr Biol 30, 2196–2203 (2020).
Zhou, H. et al. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. Cell 184, 4380–4391 (2021).
Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273 (2020).
Letko, M., Marzi, A. & Munster, V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol 5, 562–569 (2020).
Lan, J. et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 581, 215–220 (2020).
|
Sources 2/ https://www.nature.com/articles/s41597-023-02558-5 The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
