Health

Researchers identify 21 existing drugs that can treat COVID-19

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A global team of scientists has identified 21 existing drugs that stop the replication of SARS-CoV-2, the virus that causes COVID-19. In particular, four of these compounds were found to work synergistically with lemdecibir, the current standard treatment for COVID-19, says a study published in the journal. Nature.

“Rendescivir has proven successful in reducing patient recovery time in the hospital, but the drug is not effective for everyone who receives it. That’s not enough,” Sanford Burnham Previs. Sumit Chanda, a medical professor, said. Discovery Research Institute, California, USA.

“As infection rates continue to rise in the United States and around the world, finding affordable, effective, readily available medicines that can complement the use of lemdesibir, and medicines that can be given prophylactically or at the first sign of The urgency remains. Outpatient-based infection.”

In the study, the research team conducted extensive testing and validation studies, including evaluation of the drug in virus-infected human lung biopsies. They also evaluated the drug for synergy with lemdecibir and established a dose-response relationship between the drug and antiviral activity.

Of the 21 drugs that were effective in blocking viral replication, 13 were previously in clinical trials for other indications and were effective at concentrations or doses that could be safely achieved in COVID-19 patients I found out.

Two have already been approved by the US Food and Drug Administration. Astemizole (allergies) and clofazimine (Leprosy), along with lemdesibir, have received an emergency use license for COVID-19.

Four people acted synergistically with lemdecibir, including the antimalarial drug chloroquine derivative hanphantin A (tetrandrin) that has reached Phase III clinical trials.

“This study significantly expands the possible treatment options for COVID-19 patients, especially as many of the molecules already have clinical safety data in humans,” Chanda said. “This report provides the scientific community with a larger set of potential weapons that may help boost the ongoing global pandemic.”

Researchers are currently testing all 21 compounds in a small animal model that mimics human tissue and in “mini lung” or lung organoids. If these studies are beneficial, the team approaches the US FDA to discuss clinical trials evaluating drugs as treatments for COVID-19.

“Based on our current analysis, clofazimine, hanphantin A, apilimod, and ONO 5334 represent the best short-term options for effective COVID-19 treatment,” says Chanda. .. “While some of these drugs are currently in COVID-19 clinical trials, we are looking for additional drug candidates so that multiple treatment options are available if SARS-CoV-2 becomes drug resistant. Is important.”

Drugs were first identified by high-throughput screening of over 12,000 drugs from the ReFRAME Drug Transfer collection. This is the most comprehensive drug transfer collection of compounds approved by the FDA for other diseases or extensively tested for human safety.

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