Excessive consumption of meat and dairy has been increasingly associated with heightened cancer risk in recent years.
Red meat has been classified Group 2A by the World Health Organization (WHO), meaning it is ‘probably carcinogenic’ to humans. Processed meats such as ham, bacon and salami are classified a Group 1 carcinogen: known to cause cancer.
But now fresh research out of the University of Chicago suggests a nutrient found in beef, lamb, and dairy products can actually improve cancer defence. The nutrient in questions is trans-vaccenic acid (TVA).
TVA has a ‘very targeted’ mechanism
TVA is a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep. The fatty acid is also present in human milk, but the body cannot produce it on its own.
TVA was just one nutrient tested by scientists to see how it influences cancer development and responds to cancer treatments.
After first assembling a ‘blood nutrient’ compound library consisting of 255 bioactive molecules derived from nutrients, researchers screened these compounds to test their ability to influence anti-tumour immunity by activating CD8+ T cells – a group of immune cells critical for killing cancerous or virally infected cells.
Using both human and mouse cells, the six most effective compounds were selected. And of those six, it was found that TVA performed the best.
“By focusing on nutrients that can activate T cell responses, we found one that actually enhances anti-tumour immunity by activating an important immune pathway,” explained Jing Chen, the Janet Davison Rowley Distinguished Service Professor of Medicine at the University of Chicago and one of the senior authors.
Interestingly, in the body only about 20% of TVA is broken down into other by-products. The other 80% is left to circulate in the blood, which Chen suggested might mean it has another function.
“To see that a single nutrient like TVA has a very targeted mechanism on a targeted immune cell type…I find that really amazing and intriguing.”
Potential to help humans battling cancer?
To get a better understanding of TVA’s potential, the scientists conducted experiments with cells and mouse models of diverse tumour types. When mice were fed a diet enriched with TVA, tumour growth potential significantly reduced for two particular cancers types: melanoma and colon cancer. Compared to mice fed a control diet, the TVA diet also enhanced the ability of CD8+ T cells to infiltrate tumours.
Molecular and genetic analyses were conducted to try to understand exactly how TVA was affecting the T cells. It was found TVA inactivates a receptor on the cell surface called GPR43 which is usually activated by short-chain fatty acids often produced by gut microbiota.
According to the research team, TVA overpowers these short-chain fatty acids and activates a cellular signalling process called the CREB pathway. When the GPR43 receptor was removed from CD8+ T cells in mouse models, the improved tumour-fighting ability was lost.
To investigate how whether TVA has the potential to benefit humans battling cancer, the research team analysed blood samples from patients being treated with CAR-T cell immunotherapy for lymphoma. Patients that tended to respond to treatment better also had higher levels of TVA in their blood.
Testing cell lines from leukaemia revealed that TVA enhanced the ability of an immunotherapy drug to kill leukaemia cells.
Not an excuse to eat more burgers and ice cream
Before meat and dairy lovers start salivating at the idea of eating more with health in mind, the findings are not an excuse to consume more burgers and ice cream. Rather, the study suggests that TVA could be used as a dietary supplement – rather than a food source – to help various T cell-based cancer treatments.
Chen also suggested that other nutrients may have similar benefits. “There is early data showing that other fatty acids from plants signal through a similar receptor, so we believe there is a high possibility that nutrients from plants can do the same thing by activating the CREB pathway as well.”
In the future, the scientific team hopes to build a comprehensive library of nutrients circulating in the blood – just like TVA – to better understand their impact on things like immunity and ageing. “After millions of years of evolution, there are only a couple of hundred metabolites derived from food that end up circulating in the blood, so that means they could have some importance in our biology,” said Chen.
‘Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity’
Published 22 November 2023
Authors: Fat, H., Xia, S., Xiang, J. et al.
The mention sources can contact us to remove/changing this article
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- Tom Sandoval Sorry for Scandoval OJ Simpson, George Floyd Comparison – The Hollywood Reporter
- Man boasts about murders in New York City: New York City Police Department
- Capt Amarinder Singh: PM Modi wants early resolution of farm issue. Farmers must understand that this must be part of a national perspective | News from the political pulse
- NCIS Pays Moving Tribute to David McCallum in Special Episode After Actor's Death
- Aryna Sabalenka in shock scenes as tennis fans saddened by Victoria Azarenka drama
- Robbinsdale Salon Collects Ball Gowns for Fairy Godmothers Project
- Google responds to evidence of review algorithm bias
- The British Museum was bombarded by calls to return the statue
- Ankara and Cairo restore ties, signaling challenges for Muslim Brotherhood
- Château Malartic-Lagravire returns to the Hollywood red carpet as the official wine sponsor of the 37th American Cinematheque Awards
- Klarna takes on Apple, Facebook and Google with digital verification
- Building Stability: Expert Tips for Designing Earthquake-Resistant Homes