Health
“How do coronavirus molecules in host cells decode “camouflage” and lead to drug development?”
Scientists, including scientists of Indian origin, have unraveled the structure of the molecules used by the novel coronavirus to make its gene sequence appear to be part of the host itself. This is a breakthrough that could lead to the development of new antiviral drugs against Covid. 19.
According to a study published in the journal Nature Communications, the molecule nsp10 modifies viral mRNA (the blueprint for protein production) to mimic the mRNA of the host cell itself.
By enabling this change, researchers at the University of Texas San Antonio Health Science Center (UT Health San Antonio) in the United States say that nsp10 protects the virus from the host cell’s immune response.
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“It’s a camouflage. Due to the deception of the cells, the resulting viral messenger RNAs are now considered part of the cell’s own code and are not foreign,” co-authored a study by UT Health San. Yogesh Gupta said Antonio.
Decoding the 3D structure of nsp16 opens the way for new drug designs against the new coronavirus SARS-CoV-2 and other coronavirus infections, researchers say.
Gupta said these drugs could be designed to prevent nsp16 from making modifications, so that the host’s immune system could attack the invading virus and recognize it as foreign.
“Yogesh’s work discovered the 3D structure of the major enzyme of Covid-19 virus, which is required for replication, and found a pocket that could be targeted to block that enzyme. It’s a fundamental breakthrough in research,” said Robert Froma, co-author of the study.
Based on the findings, researchers have suggested structural sites on the SARS-CoV-2 nsp10 molecule that could be targeted for antiviral development.
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