Relationship between renal dysfunction and preterm birth

Women with pre-pregnancy renal failure, especially those with chronic kidney disease, are at high risk of preterm birth (premature birth) and other complications CMAJ (Canadian Medical Association Journal).

Premature delivery birth Pregnancy 37 weeks ago occurs in 6% to 11% of viable pregnancies and is the leading cause of infant death.

“Timely recognition of pregnancy kidney Dysfunction has several potential implications, including informed counseling on the risk of adverse perinatal outcomes, close monitoring of pregnant mothers and fetuses, and possible use of acetylsalicylic acid to prevent preeclampsia. There are some advantages. Is written. , Co-author.

A large study of nearly 56,000 pregnancies in Ontario, Canada, Premature delivery 7% of women with renal dysfunction compared to 37 weeks before pregnancy 7% of women with normal renal function have an average age of 30.7 years for mothers, 26% for non-whites, and 46% for the first child. It was In women with impaired renal function, the risk of severe preterm birth at or before 32 weeks was approximately doubled. 57% (2255) of all preterm births were initiated by health care providers and the remaining 43% (1701) were spontaneous.

Conclusions from previous studies on this topic are inconsistent, and survey sample sizes are often small.

The authors suggest that measuring serum creatinine in some women before pregnancy may provide a new way for clinicians to assess the risk of preterm birth.

“Given that serum creatinine measurement is a readily available and inexpensive blood test, it may have a potentially high-risk screening role. Women “Due to renal dysfunction either before or during the first trimester,” they conclude.

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Study finds changes in the interval between first and second pregnancy

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For more information:
Ziv Harel et al. Pre-pregnancy renal function and risk of preterm birth and associated outcomes, Canadian Medical Association Journal (2020). DOI: 10.1503 / cmaj.200089

Provided by
Canadian Medical Association Journal

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