Influenza and pneumonia vaccination associated with reduced risk of Alzheimer’s dementia

Vaccination against influenza and pneumonia is associated with a lower risk of Alzheimer’s disease, according to a new study reported at the Alzheimer’s Association International Conference (AAIC) 2020.

The three research studies reported in AAIC 2020 suggest that:

• At least one Flu vaccination The incidence of Alzheimer’s disease was reduced by 17%. More frequent influenza vaccination was associated with another 13% reduction in the incidence of Alzheimer’s disease.
• Vaccination against pneumonia between the ages of 65 and 75 reduced the risk of Alzheimer’s disease by up to 40%, depending on the individual gene.
• People with dementia have a higher risk of dying after infection (6 times) than people without dementia (3 times).

“With the pandemic of COVID-19, vaccines are at the forefront of public health debate. It is important to explore the benefits of vaccines as well as viruses and protection against viruses. Bacterial infection Not only can we improve long-term health outcomes,” said Dr. Maria C. Carrillo, Chief Science Officer of the Alsaheimer Society.

“It may turn out to be as simple as taking care of your health this way, ie being vaccinated, and taking care of yourself in other ways. These things lead to lower risk of Alzheimer’s disease and other dementias.” “This study is in its early stages, but we are trying to find out whether vaccination as a public health strategy reduces the risk of developing dementia with age, in a large and diverse clinical trial. Seeking research.”

Seasonal influenza vaccine may reduce the incidence of Alzheimer’s dementia

In previous studies, vaccination Cognitive declineHowever, there were no large, comprehensive studies focusing specifically on the risk of influenza vaccines and Alzheimer’s disease. To address this gap, Albert Amrun, Medical student A team and team at the McGovern Medical School at the Health Sciences Center at the University of Texas at Houston investigated a large US medical record dataset (n = 9,066).

Amran and team found that a single influenza vaccination was associated with a lower prevalence of Alzheimer’s disease (odds ratio 0.83, p

The researchers found that the protective association between the influenza vaccine and the risk of Alzheimer’s disease was strongest for those who received the first vaccine at a young age. For example, those who received the first documented flu vaccination at age 60 benefited more than those who received it.

“Our research suggests that regular access to highly accessible and relatively inexpensive interventions (flu vaccination) can significantly reduce the risk of Alzheimer’s dementia.” Said Amrun. “Exploring the biological mechanisms of this effect requires further research. Why and how it works in the body is important in exploring effective preventive therapies for Alzheimer’s disease. “

Pneumonia vaccine may reduce risk of later-stage Alzheimer’s disease

Diversion of existing vaccines may be a promising approach to the prevention of Alzheimer’s disease. Svetlana Ukraintseva, Ph.D. , An associate professor of the Research Institute for Social Biology (BARU) at the Institute of Social Sciences at Duke University, and a team investigated the association of risk with pneumococcal vaccine with and without seasonal influenza vaccination in the Cardiovascular Health Study Percentage of Alzheimer’s disease among 5,146 participants age 65 and older. The team also considered the rs2075650 G allele of the TOMM40 gene, a known genetic risk factor for Alzheimer’s disease.

Researchers found that pneumococcal vaccination at ages 65-75 reduced risk of developing Alzheimer’s disease by 25-30% after adjusting for sex, race, birth cohort, education, smoking, and G allele count I found that. The greatest reduction in risk of Alzheimer’s disease (up to 40%) was observed among people vaccinated against pneumonia, who are not carriers of the risk gene. Total vaccination against pneumonia and influenza between the ages of 65 and 75 was also associated with a reduced risk of Alzheimer’s disease. However, the flu vaccination alone was not effective.

“Vaccination against pneumonia before age 75 may reduce the risk of later-stage Alzheimer’s disease, depending on the individual genotype,” Uclinzeba said. “These data show that pneumococci vaccine In particular, it may be a promising candidate for personalized prevention of Alzheimer’s disease in non-carriers of certain risk genes. “

Infection significantly increases mortality in people with dementia

People with dementia usually experience other health conditions, such as viruses, bacteria, and other infections. Increasing research is investigating whether infections may be exacerbated, life threatening, or may cause dementia.

Dr. Janet Jembek Students and teams at the University of Copenhagen, Denmark, and Center for Dementia Research, Danish Dementia Research Center, and mortality rate for Danish residents aged 65 and over (n = 1,496,436) visited hospitals with infectious diseases. We used data from the National Health Register to investigate. They found that people with both dementia and visits to such hospitals died at a 6.5 times higher rate compared to people who had neither. Study participants with either dementia alone or only infection-related contact showed a 3-fold increase. Mortality was highest during the first 30 days after visiting the hospital.

Researchers also found that mortality in people with dementia remained elevated for 10 years after visiting hospitals associated with the first infectious disease, with all infectious diseases (from major infectious diseases such as sepsis to mild (Including ear infections), no visits to hospitals associated with dementia or infections.

“Our research supports the need to investigate these relationships further. Why infections are associated with higher mortality in people with dementia, especially what risk factors and biological mechanisms. Elucidating what is involved is a better understanding of the role of infectious diseases in dementia,” Djembek said.

“Our research is health Like relatives of people with dementia, care systems can raise awareness of people with dementia who have an infectious disease and get the medical care they need. People with dementia need more specialized treatment, even if their visit to the hospital is not a direct reason dementia But what could look like an unrelated infectious disease,” Janbek added.

Provided by the Alzheimer’s Association