Health
This seaweed extract is superior to the COVID drug lemdecivir in the lab
Rendescivir was the first major drug breakthrough in coronavirus pandemics. Studies show that some patients can recover more quickly from severe illness and have a better chance of survival. But New research It suggests that extracts from seaweed may be superior to the drug.
An extract called RPI-27 is found in the same types of seaweed you eat in sushi and helps trap the virus before it infects human cells. Researchers at the Rensselaer Polytechnic Institute have tested extracts in cell studies, as well as the anticoagulant heparin, which has a similar effect.
When someone infects with SAV-CoV-2, the virus that causes COVID-19, the virus’s spike-like proteins attach to human cell receptors and insert their genetic material. However, if another protein with the proper compatibility is already attached to the receptor, the virus will instead attach and be trapped in its place when the virus is harmlessly degraded.
“We are very pleased to meet you,” said Jonathan Doldick, Principal Investigator at the Technical University of Renseria and Professor of Chemical and Biotechnology. “Effectively, it interferes with the virus and pulls it away, so the virus can’t bind to the surface of the cell. When it’s fixed to these compounds (these seaweed extracts or heparin), they probably break down and the effect there is not.”
In laboratory cell tests, RPI-27 was almost 10 times more active than lemdecibir in blocking infection. This means that much less dose is needed to control the infection. Heparin was slightly less active than lemdecibir, but could be used therapeutically. Another test showed that the compounds worked without damaging the cells. Researchers are now beginning the next step in animal testing.
But it generally needs to be safe. “Every time you eat seaweed like sushi, you’ll get these compounds,” he says. Due to the low concentrations required and the inclusion of the compound in edible seaweed, this substance is considered GRAS or is generally recognized as safe, so treatment can get FDA approval fairly quickly. I can do it.
Heparin is usually given IV because it is used to treat blood clots. However, IV treatment can cause other problems for the patient. However, it can also be administered directly to the lungs via an inhaler. It states that it has been tested and has been shown to have little or no effect on bleeding. Because COVID-19 infections are often thought to begin in the nasal cavity, researchers are discussing the possibility of testing nasal sprays with heparin with clinical partners.
“You can dissolve this in saline just like any other nasal drop,” he says. “We can take some of it prophylactically several times a day. We expect it to bind the virus very well and essentially inactivate it. It would be a way to prevent it from reaching.” Seaweed extract could potentially be used in a similar way. It is helpful that heparin is an already approved drug, as well as lemdecibir, which had already gone through several trials of Ebola before moving to COVID-19. “These are the fastest ways to get things to patients,” he says.
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