Health
Obesity and high-fat diet are associated with accelerated aging of cerebral blood vessels
A new study conducted in mice tracks how obesity and a high-fat diet accelerate the aging of blood vessels that supply blood to the brain. The research will be presented this week at the American Physiological Society (APS)'s major annual meeting, the American Physiological Summit, in Long Beach, California.
The findings suggest that obesity and a poor diet can cause damage to accumulate in blood vessels, reducing oxygen supply to parts of the brain and ultimately leading to declines in cognitive function. I am. The study could help scientists find ways to intervene and preserve brain function in patients with obesity, which is estimated to affect about 42% of American adults.
“This project highlights the important role of vascular components and cellular aging in cognitive decline and pinpoints new potential therapeutic targets for the prevention and treatment of dementia.” said Dr. Sharon Negri, lead author and postdoctoral researcher in Stefano Tarantini's lab. He received his doctoral degree from the Department of Neurosurgery at the University of Oklahoma Health Sciences Center.
Previous research has found a strong link between obesity in midlife and increased risk of cognitive decline and dementia later in life. Scientists sought to unravel the mechanisms behind this association, with a particular focus on the role of diet and vascular health.
To do this, the researchers studied the effects of a high-fat diet on blood flow to the brain and memory in older obese mice. Using a special mouse model, researchers were also able to measure cellular senescence, the process by which cells stop dividing and making new cells. Cellular senescence increases with age and is the cause of various aging-related diseases.
Obesity can accelerate the aging of blood vessel cells in the brain, leading to aging. Establishing a link between obesity and cellular aging could open up new areas of research aimed at finding treatments to prevent or slow the aging process, and could potentially improve obesity-related health outcomes, including cognitive decline. It may be possible to alleviate the problem. ”
Dr. Sharon Negri, lead author of the study
The results showed that after three months, the mice fed the high-fat diet had increased cellular senescence and decreased density of healthy blood vessels in the brain compared to normal-weight mice, as well as a maze test. showed evidence of learning disabilities. Standard meal. Additionally, scientists found that eliminating senescent cells using Navitoclax, an investigational cancer drug that selectively kills senescent cells, improved cerebral vasculature characteristics.
If further experiments confirm that it is possible to reverse the negative effects of aging, Negri and Tarantini will next investigate whether various lifestyle interventions can help prevent or reduce cognitive impairment caused by obesity. I'm planning on evaluating it.
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