Embryos May Be Vulnerable to COVID-19 in Second Week of Pregnancy: Study

Human embryos can be infected with COVID-19 from the second week of pregnancy, scientists say

London:

According to one study, human embryos can be susceptible to COVID-19 as early as the second week of gestation if the mother becomes sick and affects the chances of successful pregnancy.

Scientists at the University of Cambridge in the United Kingdom and the California Institute of Technology in the United States have found that a gene believed to play a role in the way the SARS-CoV-2 virus infects our cells causes an early embryonic week two. I have found that I am active in pregnant.

Initially recognized as causing respiratory illness, the SARS-CoV-2 virus, which causes COVID-19 illness, also affects many other organs, they said.

Older age and obesity are risk factors for complications, but few questions are answered about possible implications for fetal health and successful pregnancy in people infected with SARS-CoV-2, according to researchers ..

In the journal Open Biology, researchers explain how to use technology to culture human embryos, usually at the stage of transplantation into the mother’s body, to examine the activity or “expression” of key genes in the embryo. did. On the surface of the SARS-CoV-2 virus are large “spike” proteins. Researchers have explained that spike proteins bind to ACE2, a protein receptor on the surface of cells in our body. Next, both the spike protein and ACE2 are cleaved, allowing the viral genetic material to enter the host cell.

The virus manipulates the machinery of the host cell, allowing the virus to replicate and spread, they said.

Researchers have discovered an expression pattern for the ACE2 gene, which provides the genetic code for the SARS-CoV-2 receptor, and TMPRSS2, which provides a molecular code that cleaves both the viral spike protein and the ACE2 receptor, leading to infection. Allowed to occur.

These genes were expressed at key stages of embryonic development and were expressed in parts of the embryo that developed into tissues that interact with the maternal blood supply for nutrient exchange.

Gene expression requires that the DNA code be first copied into the RNA message and then direct the synthesis of the encoded protein.

“Our research suggests that if a mother becomes sick, human embryos may be more susceptible to COVID-19 from the second week of pregnancy,” both Cambridge and Caltech University. Professor Magdalena Zernica Getz, who holds a position in the US, said.

“To see if this really can happen, it’s very important to know if the ACE2 and TMPRSS2 proteins are made and correctly placed on the cell surface.”

If these next steps are also taken, the virus can be transmitted from the mother and infect the embryonic cells.”

Professor David Glover, also from Cambridge and Caltech, said that genes encoding proteins that sensitize cells to infection with the novel coronavirus will be expressed very early in embryogenesis.

“This is an important step when the embryo attaches to the mother’s uterus and undergoes a major remodeling of all its tissues and begins to grow for the first time,” said David Glover.

He added that COVID-19 may affect the embryo’s ability to properly implant in the uterus or may affect future fetal health.

The team said that further research is needed using stem cell models and in non-human primates to better understand risk.

However, they said their findings underscore the importance to women who are planning to try to reduce the risk of infection for their families.

(Except for the headline, this story has not been edited by NDTV staff and has been published from the syndicate feed.)

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