Health
Coronavirus is new, but the immune system may still recognize it
While experts believe this is unlikely, existing T cells are unlikely to increase the risk of serious Covid-19 symptoms. Prepared to recognize the common cold coronavirus, T cells marshal only the dull response to the current coronavirus and excel resources from other populations of immune cells that are excellent at killing new invaders. It may rob you. “This disrupted the immune system,” said Dr. Ayer.
T cells are also a skilled orchestrator. Depending on the signal it sends, it can synchronize cells and molecules from different parts of the immune system into tagged attacks, or suppress these attacks and bring the body back to baseline. If cross-reactive T cells are found to tend to silence the response, they may suppress a person’s immune defenses before gear has the opportunity to work, Dr. August said.
Second, there are many types of T cells, all functioning as part of a complex immune system. “This is like some people are trying to describe this as “good” or “bad”,” Dr. Su said. “It’s probably more subtle than that.”
It’s not easy to break it all down. Unlike antibodies, which are inanimate proteins that often circulate in the blood, T cells are living cells that often puncture difficult-to-reach tissues. This makes extraction, maintenance, and analysis much more difficult, Dr. Pepper said.
Researchers can learn more by testing for the abundance of cross-reactive T cells in patients with mild or severe cases of Covid-19, but in such studies the cause And the effect cannot be proved. More laborious efforts may include measuring cross-reactive T cell levels in a large group of healthy people and waiting for them to become infected or sick with the current coronaviruses. Said Dr. Sette.
Strong evidence can also come from animal models such as rhesus monkeys that Dr. Ayer is studying in the lab. Researchers can give primates a common cold coronavirus and see how their immune response stacks up against the new coronavirus.
Dr. Pepper said many questions remained unanswered within a year of this pandemic. Immunologists cannot fully predict how the human immune system will respond to this new virus. Even if science is the fastest, its interactions must be studied in real time.
Dr. Pepper said it was a frustrating reality. “We don’t know until we see it in the real world.”
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