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Symptoms after COVID vaccination may indicate a strong immune response

Symptoms after COVID vaccination may indicate a strong immune response

 


Vaccination against COVID-19
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Headache, fatigue, lethargy and chills after COVID-19 vaccination are signs that the immune system is preparing a strong response against future infection, researchers suggest. study Posted today Annals of Internal Medicine.

Researchers at the University of California, San Francisco (UCSF) analyzed serum neutralizing antibody (nAB) levels against wild-type SARS-CoV-2 strains and daily symptom surveys in 363 unvaccinated, previously infection-free adults who received two doses of a 2021 mRNA COVID-19 vaccine.

About 40 percent of the participants also wore biometric devices that measured skin temperature, heart rate and breathing rate. Most of the participants were in their 40s to 60s.

Antibody levels rise after second dose

One and six months after the second vaccination, symptoms of fatigue, malaise, chills, and headache were each associated with 1.4-1.6-fold higher nAB concentrations. Participants who experienced at least seven symptoms had nAB concentrations nearly twice as high as those who reported no symptoms.

Among participants who wore biometric authentication devices,After the second dose, every 1°C (1.8°F) increase in skin temperature was associated with a 1.8-fold and 3.1-fold increase in nAB levels at 1 and 6 months, respectively.

“In general, we found that the more side effects people had, the higher the levels of antibodies they had,” said first author Ethan Dutcher, MD, PhD, of UCSF. news release“But this wasn't a hard and fast rule. Some people without side effects had better antibodies than those with side effects.”

The team noted that concerns about vaccine side effects are often a cause of hesitation to get vaccinated. “For some people, the toll of COVID-19 remains high: feeling unwell, losing work, lingering fatigue, and the dreaded long COVID-19,” co-lead author Dr. Elissa Epel said in a statement. “Although symptoms from the vaccination can be very unpleasant, it's important to remember that these symptoms pale in comparison to the potential complications of the disease,” she said.

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2/ https://www.cidrap.umn.edu/covid-19/having-symptoms-after-getting-covid-vaccine-may-indicate-robust-immune-response

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