Health
Germ cells drive sex-specific lifespan differences in vertebrates
Women live longer than men. This is not unique to humans, but is a trend seen in many other animals as well. Biologists theorize that the difference in life expectancy between the sexes may be partly to do with reproduction, but how?
In published studies, Scientific progress, Researchers at Osaka University have discovered for the first time that germ cells, which develop into eggs in females and sperm in males, drive sex-specific differences in lifespan in vertebrates.
The researchers studied aging in turquoise killifish, a small, fast-growing freshwater fish that only lives for a few months. Like humans, female killifish live longer than males. But when the researchers removed reproductive cells from these fish, they found that males and females had roughly the same lifespan.
“After removing the germ cells, male medaka lived longer than normal, while females' lifespans were shortened,” explains lead author Kota Abe. “We wanted to understand why germ cells have such different effects on males and females. Our next step was to investigate the factors that cause this.”
The team found that hormone signaling differs significantly between females and males. Female killifish, which lack germ cells, have significantly less estrogen signaling, which can increase the risk of cardiovascular disease and shorten lifespan. Females also have significantly more growth factor signaling (insulin-like growth factor 1), which allows them to grow larger but also suppresses internal signals that are important for maintaining health and slowing aging.
In contrast, male killifish, which lack germ cells, had improved muscle, skin and bone health. Interestingly, these fish had increased amounts of a substance that activates vitamin D, and there was also evidence of vitamin D signaling in muscles and skin.
“Vitamin D, which can be thought of as a hormone, is best known for keeping bones strong and healthy, but it also appears to have broader positive effects throughout the body. The team's results suggest that vitamin D may extend lifespan, which prompted them to test whether vitamin D supplements could extend lifespan in fish.”
“When we administered active vitamin D, we found that lifespan was significantly extended in both males and females, indicating that vitamin D signaling confers health benefits throughout the body. Our study suggests that vitamin D signaling may influence lifespan in other vertebrates, including humans.”
Toru Ishitani, Senior Author
The discovery that germ cells have opposing effects on male and female lifespan provides an important clue to unraveling the mysterious interplay between reproduction, aging and lifespan. Exactly how vitamin D fits into this puzzle is unclear, but it may be part of a future strategy to extend healthy lifespan.
sauce:
Journal References:
Abe, K. other(2024). Sex-dependent control of vertebrate somatic cell growth and aging by germ cells. Scientific advances. translation:.
|
Sources 2/ https://www.news-medical.net/news/20240612/Germ-cells-drive-sex-dependent-lifespan-differences-in-vertebrate-animals.aspx The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
